Simultaneous multi-banding and multi-echo phase encoding for the accelerated acquisition of high-resolution volumetric diffusivity maps by spatiotemporally encoded MRI

Abstract

Purpose: Spatiotemporal Encoding (SPEN) is an ultrafast imaging technique where the low-bandwidth axis is rasterized in a joint spatial/k-domain. SPEN benefits from increased robustness to field inhomogeneities, folding-free reconstruction of subsampled data, and an ability to combine multiple interleaved or signal averaged scans -yet its relatively high SAR complicates volumetric uses. Here we show how this can be alleviated by merging simultaneous multi-band excitation, with intra-slab multi-echo (ME) phase encoding, for the acquisition of high definition volumetric DWI/DTI data.

Methods: A protocol involving phase-cycling of simultaneous multi-banded z-slab excitations in independently k_y-interleaved scans, together with ME trains that k_z-encoded positions within these slabs, was implemented. A reconstruction incorporating a CAIPIRINHA-like encoding of the multiple bands and exploiting SPEN's ability to deliver self-referenced, per-shot phase maps, then led to high-definition diffusivity acquisitions, with reduced SAR and acquisition times vis-à-vis non-optimized 3D counterparts.

Results: The new protocol was used to collect full brain 3 T DTI experiments at a variety of nominal voxel sizes, ranging from 1.95 to 2.54 mm³. In general, the new protocol yielded superior sensitivity and fewer distortions than what could be observed in comparably timed phase-encoded 3D SPEN, multi-slice 2D SPEN, or optimized EPI counterparts.

Conclusions: A robust procedure for acquiring volumetric DWI/DTI data was developed and demonstrated.

Keywords: Fast volumetric MRI; Inter-scan correction; Regularized reconstruction; Simultaneous multi-slicing; Spatiotemporal encoding (SPEN).