Differential phosphorylation of microtubule proteins by ATP and GTP
- PMID: 3374479
- DOI: 10.1007/BF00229400
Differential phosphorylation of microtubule proteins by ATP and GTP
Abstract
Purified brain microtubule protein is phosphorylated by endogenous protein kinase activities in the presence of [gamma-32P] ATP or [gamma-32P] GTP. Here we show that certain microtubule-associated proteins are phosphorylated differently by GTP or ATP as direct phosphoryl donors, suggesting the presence of distinct kinase activities, with different specificities, associated with microtubule protein.
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