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. 2021 Aug;48(8):1027-1033.
doi: 10.1111/cup.13987. Epub 2021 Apr 6.

High-risk human papillomavirus and ZEB1 in ocular adnexal sebaceous carcinoma

Robert F Moore  1 , Xinhai R Zhang  2 , Derek B Allison  3 , Lisa M Rooper  4 , Ashley A Campbell  5 , Charles G Eberhart  4   5
Affiliations

High-risk human papillomavirus and ZEB1 in ocular adnexal sebaceous carcinoma

Robert F Moore et al. J Cutan Pathol. 2021 Aug.

Abstract

Background: Ocular adnexal (OA) sebaceous carcinoma is an aggressive malignancy. Oncologic drivers of ocular sebaceous carcinoma are incompletely understood.

Methods: A retrospective search of our pathology archives for OA sebaceous carcinoma identified 18 primary resection specimens. Immunohistochemistry for p16 and ZEB1 and RNA in situ hybridization for high-risk human papillomavirus (HPV) subtypes were performed.

Results: High-risk HPV was demonstrated in 2/11 (18%) cases. p16 overexpression was observed in 10/11 (91%). No association between gender, age at presentation, tumor location, intraepithelial spread, tumor size, and T stage was observed between HPV-driven and nonviral cases. High expression of ZEB1 was observed in the intraepithelial component of 4/14 (28%) cases and in the subepithelial component of 1/13 (7%) cases. ZEB1 overexpression was not associated with HPV status, T stage, or tumor size.

Conclusion: As previously described by others, our findings suggest that a subset of OA sebaceous carcinomas may arise via an HPV-dependent pathway. However, unlike high-risk HPV-driven carcinomas of the oropharynx, we did not identify an association between HPV-status and prognostic features. Furthermore, p16 expression was not a useful surrogate marker for HPV-driven disease. ZEB1 overexpression is not associated with HPV in our cohort of ocular sebaceous carcinoma.

Keywords: ZEB1; high-risk HPV; ocular adnexal tumor; sebaceous carcinoma.

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