Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Apr;99(4):808-811.
doi: 10.1016/j.kint.2020.12.032.

New GFR-estimating equations for children and young adults in North America and Europe

Lesley A Inker  1 , Andrew S Levey  2
Affiliations
Comment

New GFR-estimating equations for children and young adults in North America and Europe

Lesley A Inker et al. Kidney Int. 2021 Apr.

Abstract

For application to general populations, estimating equations for glomerular filtration rate should be developed and validated in diverse populations, including a wide range of age, race-ethnicity, and clinical conditions. This issue includes reports on the development of new equations by 2 research groups to improve glomerular filtration rate estimation in children and young adults. Both equations performed better than guideline-recommended equations, but both require further evaluation of generalizability, and neither fulfills the goal of development in a diverse population.

PubMed Disclaimer

Conflict of interest statement

Disclosure

All the authors declared no competing interests.

Comment on

References

    1. Levey AS, Coresh J, Tighiouart H, et al. Strengths and limitations of estimated and measured GFR. Nat Rev Nephrol. 2019; 15:784. - PubMed
    1. Diao J, Tighiouart H, Inker L, Levey A, Powe N, Manrai A. In Search of a Better Equation - Performance and Equity in Estimates of Kidney Function. N Engl J Med. 2021; 384:396–399 - PMC - PubMed
    1. Inker LA, Couture SJ, Tighiouart H, et al. A New Panel eGFR, including Beta-2 Microglobulin and Beta Trace Protein and not including Race, Developed in a Diverse Population [e-pub ahead of print]. American Journal of Kidney Disease. 10.1053/j.ajkd.2020.11.005. Accessed February 12, 2021 - DOI - PMC - PubMed
    1. Miller WG, Jones GRD. Estimated Glomerular Filtration Rate; Laboratory Implementation and Current Global Status. Adv Chronic Kidney Dis. 2018;25(1):7–13. - PubMed
    1. Pierce CB, Muñoz A, Ng DK,et al. Age and Sex Dependent Clinical Equations to Estimate Glomerular Filtration Rates in Children and Young Adults with Chronic Kidney Disease. Kidney Int. 2021; 99:948–956 - PMC - PubMed

LinkOut - more resources