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. 2021 Feb 20;46(1):3-6.
doi: 10.1584/jpestics.M21-03.

New ways and new hopes for IGR development

Marek Jindra  1
Affiliations

New ways and new hopes for IGR development

Marek Jindra. J Pestic Sci. .

Abstract

Insect Growth Regulators (IGRs) represent advanced, bio-rational insecticides. This Special Issue reflects progress in IGR development that has been enabled by insight into the molecular principles of biosynthetic or hormone signaling pathways. The unifying principle is aiming at processes and molecular targets that are unique to arthropods and ideally to narrower insect taxa representing pests or disease vectors. While some strategies of obtaining the desired compounds for chemical intervention rely on rational, structure-based design or computational power, others exploit technologies allowing automated, high-throughput screening of large chemical libraries. All avenues leading to selective and environmentally safe pest control are valid as we face the imminent threat of the declining world insect population.

Keywords: biosynthesis; ecdysone; juvenile hormone; metamorphosis; molting; receptors.

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