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. 2020 Sep;12(3):202-207.
doi: 10.1007/s11930-020-00273-5. Epub 2020 Jul 17.

The Seminal Microbiome and Male Factor Infertility

Vadim Osadchiy  1   2 , Jesse N Mills  1 , Emeran A Mayer  2 , Sriram V Eleswarapu  1
Affiliations

The Seminal Microbiome and Male Factor Infertility

Vadim Osadchiy et al. Curr Sex Health Rep. 2020 Sep.

Abstract

Purpose of review: Focusing on studies published within the last decade, we review the literature on the seminal microbiome and male factor infertility. We highlight potential mechanisms by which microbes may impact fertility and underscore key limitations and clinical implications of these studies.

Recent findings: The seminal microbiome encompasses a metabolically and phylogenetically diverse group of microorganisms. Lactobacillus was consistently associated with normal semen analysis parameters and fertility; Anaerococcus was negatively associated with semen quality. These microbes may participate in a complex cross-talk with the host immune system, thereby modulating local and perhaps systemic inflammatory responses, impacting semen quality.

Summary: Research investigating the intersection between the seminal microbiome and male fertility is still in its infancy. Recent investigations have been exclusively cross-sectional, correlational studies, limiting the clinical applicability of published research. Prospective studies with more sophisticated methodologies are necessary.

Keywords: Anaerococcus; Male Infertility; Next Generation Sequencing; Semen Microbiome.

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Conflict of interest statement

Declaration of Interest SVE is a consultant for Metuchen Pharmaceuticals. JNM is a consultant for Antares Pharma, Boston Scientific, and Endo Pharmaceuticals. VO and EAM declares no competing interests.

References

    1. Osadchiy V, Martin CR, Mayer EA. The Gut-Brain Axis and the Microbiome: Mechanisms and Clinical Implications. Clin Gastroenterol Hepatol. 2019;17(2):322–32. - PMC - PubMed
    1. Golombos DM, Ayangbesan A, O’Malley P, Lewicki P, Barlow L, Barbieri CE, et al. The Role of Gut Microbiome in the Pathogenesis of Prostate Cancer: A Prospective, Pilot Study. Urology. 2018;111:122–8. - PubMed
    1. Sirota I, Zarek SM, Segars JH. Potential influence of the microbiome on infertility and assisted reproductive technology. Semin Reprod Med. 2014;32(1):35–42. - PMC - PubMed
    1. Gimenes F, Souza RP, Bento JC, Teixeira JJ, Maria-Engler SS, Bonini MG, et al. Male infertility: a public health issue caused by sexually transmitted pathogens. Nat Rev Urol. 2014;11(12):672–87. - PubMed
    1. Jungwirth A, Giwercman A, Tournaye H, Diemer T, Kopa Z, Dohle G, et al. European Association of Urology guidelines on Male Infertility: the 2012 update. Eur Urol. 2012;62(2):324–32. - PubMed