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Review
. 2021 Mar 2:2021:8874990.
doi: 10.1155/2021/8874990. eCollection 2021.

Diagnostic Accuracy of 18F-FDG-PET/CT and MRI in Predicting the Tumor Response in Locally Advanced Cervical Carcinoma Treated by Chemoradiotherapy: A Meta-Analysis

Sharareh Sanei Sistani  1 , Fateme Parooie  2 , Morteza Salarzaei  2
Affiliations
Review

Diagnostic Accuracy of 18F-FDG-PET/CT and MRI in Predicting the Tumor Response in Locally Advanced Cervical Carcinoma Treated by Chemoradiotherapy: A Meta-Analysis

Sharareh Sanei Sistani et al. Contrast Media Mol Imaging. .

Abstract

Objective: The aim of this meta-analysis was to compare the diagnostic accuracy of 18F-FDG-PET/CT and MRI in predicting the tumor response in locally advanced cervical carcinoma (LACC) treated by chemoradiotherapy (CRT).

Method: This meta-analysis has been performed according to PRISMA guidelines. Systematic searches were conducted using PubMed and Embase databases for articles published from January 1, 2010, to January 1, 2020. By using the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool, the reviewers assessed the methodological quality scores of the selected studies. We analyzed the sensitivity, specificity, and accuracy of two diagnostic methods using Meta-DiSc 1.4 and Stata 15.

Results: An overall of 15 studies including 1132 patients were included. Sensitivities of PET/CT and MRI were 83.5% and 82.7%, while the corresponding rates for specificities were 77.8% and 68.4%, respectively. The DOR, PLR, and NLR for MRI were 15.140, 2.92, and 22.6. PET/CT had a DOR of 25.21. The PLR and NLR for PET/CT were 4.13 and 0.215, respectively. The diagnostic sensitivity and specificity of PET/CT for the detection of residual tumor were 86% and 95%, respectively. The corresponding rates for MRI were 73% and 96%, respectively. The diagnostic sensitivity and specificity of PET/CT for the detection of tumor metastases were 97% and 99%, while the corresponding rates for MRI were 31% and 98%, respectively.

Conclusion: 18F-FDG PET/CT seemed to have a better overall diagnostic accuracy in the evaluation of treatment response to chemoradiotherapy in LACC patients. MRI showed a really poor sensitivity in the detection of metastases, and PET/CT performed significantly better. However, the difference between these two methods in the detection of residual disease was not significant. More studies are needed to be conducted in order to approve that 18F-FDG PET/CT can be a standard option to assess the treatment response.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram.
Figure 2
Figure 2
QUADS-2 for the evaluation of methodological quality.
Figure 3
Figure 3
Hierarchical summary receiver (HSROC) curve for MRI (a) and 18F-FDG PET/CT (b) for predicting treatment response in LACC patients after CRT.
Figure 4
Figure 4
PLR and NLR of 18F-FDG PET/CT (b) and MRI (a) for predicting treatment response in LACC patients after CRT based on countries.
Figure 5
Figure 5
DOR of 18F-FDG PET/CT (b) and MRI (a) for predicting treatment response in LACC patients after CRT based on countries.
Figure 6
Figure 6
Fagan's nomogram for the calculation of posttest probabilities of MRI (a) and PET/CT (b).
See this image and copyright information in PMC

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