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. 2021 Mar 1;14(3):100527.
doi: 10.1016/j.waojou.2021.100527. eCollection 2021 Mar.

Skin manifestations in pediatric patients with primary immunodeficiency diseases (PIDs) in a tertiary care hospital in Colombia

William López-Quintero  1   2 , Daniela Cleves  3   4 , Jose David Gomez-Vasco  2 , Paola Pérez  4   5 , Jaime Patiño  4   5 , Diego Medina-Valencia  4   6 , Harry Pachajoa  2   7 , Laura Torres-Canchala  3 , Andres Vidal  1   2 , Manuela Olaya  4   8
Affiliations

Skin manifestations in pediatric patients with primary immunodeficiency diseases (PIDs) in a tertiary care hospital in Colombia

William López-Quintero et al. World Allergy Organ J. .

Abstract

Background: The current literature describes the characteristics of some skin manifestations in the context of primary immunodeficiency diseases (PIDs), also known as inborn errors of the immune system. However, there are hardly any data on the epidemiological trends of skin manifestations and PIDs in Latin America (LA). We aimed to describe the characteristics of patients with skin manifestations and the diagnosis of a PID treated at a tertiary hospital in Colombia.

Methods: This was a retrospective observational study. Data were taken from the institutional database of pediatric PIDs, which includes 306 patients under 18 years of age who attended a tertiary care center in Cali, Colombia for inpatient or outpatient services between December 2013 and December 2018. A trained third-year dermatology resident reviewed the electronic clinical records of all the patients in the database and double-checked patients who presented with cutaneous signs and symptoms.

Results: A total of 83 patients out of the original 306 patients (27.1%) presented with some type of cutaneous manifestation. Of these patients, 56.6% had atopic dermatitis, 56.6% reported at least one episode of skin infection, and some of the patients had both of these manifestations. Infections were more frequent in the PID group of combined immunodeficiency associated with well-defined syndromes and atopic dermatitis in the group of antibody deficiencies.

Conclusions: It is important to recognize dermatological clinical characteristics in patients with PIDs. More studies are necessary to establish recommendations regarding the approach of diagnosis and management of these patients.

Keywords: Atopic dermatitis; Cutaneous manifestations; Inborn errors of immunity; Primary immunodeficiency diseases; Skin infection.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Distribution of PID diagnosis according to IUIS classification in pediatric patients with PIDs and cutaneous manifestations treated in a tertiary hospital in Colombia between 2013 and 2018
Fig. 2
Fig. 2
Cutaneous Manifestations in Patients with PIDs treated in a tertiary hospital in Colombia between 2013 and 2018
See this image and copyright information in PMC

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