Primary squamous cell carcinoma of renal parenchyma: Case report and review of literature

Abstract

Primary squamous cell carcinoma (SCC) of renal parenchyma is very rare and until now only a few cases have been reported. We report a unique SCC case in terms of aggressive nature and metastatic pattern. Renal rubber consistency and pasty keratin secretions were important findings in our patient. The patient underwent radical nephrectomy and lymphadenectomy and received 4 cycles of chemotherapy with cisplatin and gemcitabine. Eight month later, she succumbed the disease after developing ovary metastasis and not responding to chemotherapy. Also, our study showed that SCC may be present in pyelonephritic kidneys without a specific radiologic finding.

Keywords: Kidney; Lymphadenectomy; Nephrectomy; Pyelonephritis; Squamous cell carcinoma.

Fig. 1

A- Non-contrast abdominal CT scan coronal image, severely enlarged left kidney with several varying size stones and para-aortic lymph nodes; B- Axial abdominal CT scan without contrast, left kidney enlargement with a large stone and an apparent para-aortic lymph node; C- Abdominal X-ray image, left kidney enlargement along with innumerable varying size stones.

Fig. 2

A- Two glomeruli in the right side and tumor in the left side; B- Extensive keratin pearls; C- Squamous cell carcinoma nearby a glomerulus, D- Normal pelvis, not involved with tumor.