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Review
. 2021 Mar 5:7:616524.
doi: 10.3389/fmed.2020.616524. eCollection 2020.

Management of Staphylococcus aureus Bloodstream Infections

Affiliations
Review

Management of Staphylococcus aureus Bloodstream Infections

Aurelia Kimmig et al. Front Med (Lausanne). .

Abstract

Staphylococcus aureus bloodstream infections are associated with a high morbidity and mortality. Nevertheless, significance of a positive blood culture with this pathogen is often underestimated or findings are misinterpreted as contamination, which can result in inadequate diagnostic and therapeutic consequences. We here review and discuss current diagnostic and therapeutic key elements and open questions for the management of Staphylococcus aureus bloodstream infections.

Keywords: Staphylococcus aureus blood stream infections; current recommendations; diagnostic and therapeutic algorithm; endocarditis; open questions.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Diagnostic algorithm.
Figure 2
Figure 2
Antibiotic treatment algorithm.

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References

    1. Laupland KB, Lyytikäinen O, Søgaard M, Kennedy KJ, Knudsen JD, Ostergaard C, et al. . The changing epidemiology of Staphylococcus aureus bloodstream infection: a multinational population-based surveillance study. Clin Microbiol Infect. (2013) 19:465–71. 10.1111/j.1469-0691.2012.03903.x - DOI - PubMed
    1. Nambiar K, Seifert H, Rieg S, Kern WV, Scarborough M, Gordon NC, et al. . Survival following Staphylococcus aureus bloodstream infection: a prospective multinational cohort study assessing the impact of place of care. J Infect. (2018) 77:516–25. 10.1016/j.jinf.2018.08.015 - DOI - PubMed
    1. Thwaites GE, Scarborough M, Szubert A, Nsutebu E, Tilley R, Greig J, et al. . Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. (2018) 391:668–78. 10.1016/S0140-6736(17)32456-X - DOI - PMC - PubMed
    1. Garzoni C, Kelley WL. Staphylococcus aureus: new evidence for intracellular persistence. Trends Microbiol. (2009) 17:59–65. 10.1016/j.tim.2008.11.005 - DOI - PubMed
    1. Strobel M, Pförtner H, Tuchscherr L, Völker U, Schmidt F, Kramko N, et al. . Post-invasion events after infection with Staphylococcus aureus are strongly dependent on both the host cell type and the infecting S. aureus strain. Clin Microbiol Infect. (2016) 22:799–809. 10.1016/j.cmi.2016.06.020 - DOI - PubMed

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