Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Mar 4:8:635060.
doi: 10.3389/fsurg.2021.635060. eCollection 2021.

Current Management of Membranous Urethral Strictures Due to Radiation

Marjan Waterloos  1   2 , Francisco Martins  3 , Wesley Verla  2 , Luis Alex Kluth  4 , Nicolaas Lumen  2
Affiliations
Review

Current Management of Membranous Urethral Strictures Due to Radiation

Marjan Waterloos et al. Front Surg. .

Abstract

Radiotherapy is a frequently used treatment for prostate cancer. It does not only causes the intended damage to cancer cells, but also affects healthy surrounding tissue. As a result radiation-induced urethral strictures occur in 2.2% of prostate cancer patients. Management of urethral strictures is challenging due to the presence of poor vascularized tissue for reconstruction and the proximity of the sphincter, which can impair the functional outcome. This review provides a literature overview of risk factors, diagnostics and management of radiation-induced urethral strictures.

Keywords: membranous urethral stricture; radiation-induced; radiotherapy; urethal stricture; urethroplasty.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Similar articles

See all similar articles

Cited by

References

    1. Awad MA, Gaither TW, Osterberg EC, Murphy GP, Baradaran N, Breyer BN. Prostate cancer radiation and urethral strictures: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis. (2018) 21:168–74. 10.1038/s41391-017-0028-3 - DOI - PubMed
    1. Herschorn S, Elliott S, Coburn M, Wessells H, Zinman L. SIU/ICUD consultation on urethral strictures: posterior urethral stenosis after treatment of prostate cancer. Urology. (2014) 83 (3 Suppl.):S59–70. 10.1016/j.urology.2013.08.036 - DOI - PubMed
    1. Stone HB, Coleman CN, Anscher MS, McBride WH. Effects of radiation on normal tissue: consequences and mechanisms. Lancet Oncol. (2003) 4:529–36. 10.1016/S1470-2045(03)01191-4 - DOI - PubMed
    1. Sullivan L, Williams SG, Tai KH, Foroudi F, Cleeve L, Duchesne GM. Urethral stricture following high dose rate brachytherapy for prostate cancer. Radiother Oncol. (2009) 91:232–6. 10.1016/j.radonc.2008.11.013 - DOI - PubMed
    1. Hughes M, Caza T, Li G, Daugherty M, Blakley S, Nikolavsky D. Histologic characterization of the post-radiation urethral stenosis in men treated for prostate cancer. World J Urol. (2020) 38:2269–77. 10.1007/s00345-019-03031-y - DOI - PubMed