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Review
. 2021 Mar 5:8:631817.
doi: 10.3389/fcvm.2021.631817. eCollection 2021.

Myocardial Infarction: The Protective Role of MiRNAs in Myocardium Pathology

Wei Wang  1 , Hao Zheng  2
Affiliations
Review

Myocardial Infarction: The Protective Role of MiRNAs in Myocardium Pathology

Wei Wang et al. Front Cardiovasc Med. .

Abstract

Cardiovascular diseases have been regarded as the leading cause of death around the world, with myocardial infarction (MI) being the most severe form. MI leads to myocardial apoptosis, cardiomyocyte fibrosis, and cardiomyocyte hypertrophy, ultimately leading to heart failure, and death. Micro RNAs (miRNAs) participate in the genesis and progression of myocardial pathology after MI by playing an important regulatory role. This review aims to summarize all available knowledge on the role of miRNAs in the myocardial pathological process after MI to uncover potential major target pathways. In addition, the main therapeutic methods and their latest progress are also reviewed. miRNAs can regulate the main signaling pathways as well as pathological processes. Thus, they have the potential to induce therapeutic effects. Hence, the combination of miRNAs with recently developed exosome nanocomplexes may represent the future direction of therapeutics.

Keywords: MI; apoptosis; fibrosis; hypertrophy; miRNA.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
miRNAs form and function.
Figure 2
Figure 2
miRNAs target myocardium in pathological process after MI. miRNAs are involved in myocardial cell apoptosis, myocardial fibrosis, and myocardial hypertrophy acting on myocardial targets after MI. Upregulation of red miRNAs promoted the development of pathology, while upregulation of green miRNAs inhibited or even reversed the pathological process.
See this image and copyright information in PMC

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