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Comment
. 2021 May;62(5):631-634.
doi: 10.1111/jcpp.13416. Epub 2021 Mar 21.

Commentary: Meeting the challenge of multidimensionality in neurodevelopmental disorders-reflections on Johnson et al. (2021)

Laurie J Hannigan  1   2 , Alexandra Havdahl  1   2   3   4
Affiliations
Comment

Commentary: Meeting the challenge of multidimensionality in neurodevelopmental disorders-reflections on Johnson et al. (2021)

Laurie J Hannigan et al. J Child Psychol Psychiatry. 2021 May.

Abstract

Neurodevelopmental disorders are widely acknowledged to be complex and multifactorial in origin, but this is rarely reflected in the approaches used to study them. We reflect on the 2021 Annual Research review and its introduction of a new conceptual framework designed to make the complexity of early neurodevelopment more empirically tractable. We evaluate the review authors' justification, explanation, and guidance for implementation of their framework in the context of their stated goals and highlight key assumptions that support its conceptual validity. Finally, we offer a genetic epidemiological perspective on potential applications, suggesting ways in which genomic data can be used to elucidate causal mechanistic processes within the AMEND framework.

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References

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