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. 2021 May;38(3):704-706.
doi: 10.1111/pde.14576. Epub 2021 Mar 21.

Clinical characteristics associated with increased wound size in patients with recessive dystrophic epidermolysis bullosa

Daniel C Solis  1 , Emily S Gorell  2   3 , Claudia Teng  2 , Melissa Barriga  2 , Jaron Nazaroff  4 , Shufeng Li  2 , Andrew Subica  1 , Ying Lu  5 , M Peter Marinkovich  2   6 , Jean Y Tang  2
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Clinical characteristics associated with increased wound size in patients with recessive dystrophic epidermolysis bullosa

Daniel C Solis et al. Pediatr Dermatol. 2021 May.

Abstract

As more therapeutic clinical trials focus on treatment of individual wounds in patients with recessive dystrophic epidermolysis bullosa, it has become crucial to understand the baseline clinical characteristics of these wounds. To investigate these features, we administered an RDEB-specific wound survey. Forty participants reported on location, size, pain, infection frequency, wound type, and duration of 189 wounds; a subset of 22 participants reported on pruritus in 63 wounds. Increased wound size was significantly associated with increased pain, increased pruritus, longer wound duration, increased infection frequency, and patients with mutations resulting in truncated type VII collagen.

Keywords: epidermolysis bullosa; genodermatoses; pain; pruritus; surveys and questionnaires; wound healing.

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References

REFERENCES

    1. Solis DC, Teng C, Gorell ES, et al. Classification of two distinct wound types in recessive dystrophic epidermolysis bullosa: a retrospective and cohort natural history study. J Am Acad Dermatol. 2020;S0190-9622(20):32579-32572. https://doi.org/10.1016/j.jaad.2020.08.118.
    1. https://clinicaltrials.gov/ct2/results?cond=epidermolysis+bullosa. Accessed December 13, 2020.
    1. Eng VA, Solis DC, Gorell ES, et al. Patient-reported outcomes and quality of life in recessive dystrophic epidermolysis bullosa: a global cross-sectional survey. J Am Acad Dermatol. 2020;9622(20):30442-30444.
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