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Comment
. 2021 May 3;218(5):e20210286.
doi: 10.1084/jem.20210286.

Immune-mediated vincristine-induced neuropathy: Unlocking therapies

Masha G Savelieff  1 , Eva L Feldman  1   2
Affiliations
Comment

Immune-mediated vincristine-induced neuropathy: Unlocking therapies

Masha G Savelieff et al. J Exp Med. .

Abstract

Vincristine-induced peripheral neuropathy (VIPN) is a prevalent and painful complication in cancer patients that lacks effective treatments. In this issue of JEM, Starobova et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201452) report that VIPN is driven by innate immune system activation, a discovery that unlocks immunotherapies as potential treatments.

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Figures

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Insights from Masha G. Savelieff and Eva L. Feldman.
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Overview of neuropathies with known and emergent immune involvement. Homeostatic innate and adaptive immune function, blue. Injury-inducing signal(s) lead(s) to immune involvement and infiltration into the nerve, causing motor and sensory neuropathy, red. Created, in part, with BioRender.com.
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References

    1. Bourque, P.R., et al. 2015. Clin. Chim. Acta. 10.1016/j.cca.2015.02.039 - DOI
    1. Callaghan, B.C., et al. 2020. JAMA. 10.1001/jama.2020.0700 - DOI
    1. Davies, A.J., et al. 2019. Cell. 10.1016/j.cell.2018.12.022 - DOI
    1. Davoli-Ferreira, M., et al. 2020. Pain. 10.1097/j.pain.0000000000001879 - DOI
    1. Elzinga, S., et al. 2019. Exp. Neurol. 10.1016/j.expneurol.2019.112967 - DOI - PMC - PubMed

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