Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec;23(4):466-470.
doi: 10.1007/s12017-021-08652-4. Epub 2021 Mar 22.

Assessment of Peripheral Blood Lymphocytes in Parents of Autistic Children by Cytokinesis Block Micronucleus Assay

Parisa Moeinian  1   2 , Rasoul Alizadeh  2 , Mitra Hakim Shooshtari  3 , Hossein Mozdarani  4 , Fatemeh Yousefi Laksari  5 , Fatemeh Taherizadeh  6 , Zahra Mortazavi  7 , Mansoureh Akouchekian  8   9
Affiliations

Assessment of Peripheral Blood Lymphocytes in Parents of Autistic Children by Cytokinesis Block Micronucleus Assay

Parisa Moeinian et al. Neuromolecular Med. 2021 Dec.

Abstract

Autism spectrum disorders are neurodevelopmental complex diseases with causative de-novo and inherited genetic factors. They include a range of cognitive and behavioral conditions such as pervasive developmental disorder, Asperger's syndrome, and autism. Cytokinesis-block micronucleus assay, as a cytogenetic study has been considered as one of the indicators of chromosomal damage in peripheral blood. This study aimed to investigate the frequency of micronucleus (MN) in peripheral blood lymphocytes of parents with autistic children. The study was case-control and the cases were parents of autistic children referring to the psychiatric department of the Ali-Asghar Hospital of Tehran. The total number of samples was 60 cases and 30 controls. The results showed that autistic children's parents had a significant increase in MN frequency in binucleated lymphocytes. Further researches are suggested to analyze the environmental and genetic reasons for MN increase in autistic children parents.

Keywords: Autism; Chromosomal damage; Cytogenetic; Micronucleus.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Chaste, P., & Leboyer, M. (2012). Autism risk factors: Genes, environment, and gene-environment interactions. Dialogues in Clinical Neuroscience, 14(3), 281-292. - DOI
    1. Baio, J., Wiggins, L., Christensen, D. L., Maenner, M. J., Daniels, J., Warren, Z., Kurzius-Spencer, M., Zahorodny, W., Robinson Rosenberg, C., & White, T. (2018). Correction and republication: Prevalence and characteristics of autism spectrum disorder among children aged 8 years—autism and developmental disabilities monitoring network, 11 sites, United States, 2012. MMWR Morbidity and Mortality Weekly Report, 67(45), 1279. https://doi.org/10.15585/mmwr.mm6745a7 - DOI
    1. Eskenazi, B., & Castorina, R. (1999). Association of prenatal maternal or postnatal child environmental tobacco smoke exposure and neurodevelopmental and behavioral problems in children. Environmental Health Perspectives, 107(12), 991–1000. https://doi.org/10.1289/ehp.99107991 - DOI - PubMed - PMC
    1. Geetha, B., Sukumar, C., Dhivyadeepa, E., Reddy, J. K., & Balachandar, V. (2018). Autism in India: A case-control study to understand the association between socio-economic and environmental risk factors. Acta Neurologica Belgica. https://doi.org/10.1007/s13760-018-01057-4 - DOI - PubMed
    1. Grandjean, P., & Landrigan, P. J. (2006). Developmental neurotoxicity of industrial chemicals. The Lancet, 368(9553), 2167–2178. https://doi.org/10.1016/s0140-6736(06)69665-7 - DOI

Publication types

LinkOut - more resources