Function of pH-dependent transcription factor PacC in regulating development, pathogenicity, and mycotoxin biosynthesis of phytopathogenic fungi
- PMID: 33751796
- DOI: 10.1111/febs.15808
Function of pH-dependent transcription factor PacC in regulating development, pathogenicity, and mycotoxin biosynthesis of phytopathogenic fungi
Abstract
pH, as one of the most important environmental factors, affects various biological processes in pathogenic fungi. Sensing and responding to fluctuations in ambient pH are essential for these fungi to complete their life cycle. Fungi have evolved a complicated and conserved system, the so-called Pal-pH pathway, to regulate genes and adapt to alterations in ambient pH. PacC is the dominant transcription factor in the Pal-pH pathway and regulates various biological processes. The regulatory mode of PacC has been extensively studied in Aspergillus nidulans and is generally conserved in other fungal species, including numerous phytopathogenic fungi. However, species-specific alterations have been reported. This review summarizes recent advances in the regulatory mechanisms of PacC and its role in controlling development, pathogenicity, and mycotoxin biosynthesis in phytopathogenic fungi. Potential applications of these findings and some unresolved questions are also discussed.
Keywords: PacC; fungal pathogen; mycotoxin; pH signaling pathway; pathogenicity; plant host.
© 2021 Federation of European Biochemical Societies.
Similar articles
-
pH regulation of gene expression in fungi.Fungal Genet Biol. 2000 Mar;29(2):61-71. doi: 10.1006/fgbi.2000.1188. Fungal Genet Biol. 2000. PMID: 10919375 Review.
-
Activation of the Aspergillus PacC transcription factor in response to alkaline ambient pH requires proteolysis of the carboxy-terminal moiety.Genes Dev. 1995 Jul 1;9(13):1622-32. doi: 10.1101/gad.9.13.1622. Genes Dev. 1995. PMID: 7628696
-
The pH signalling transcription factor PacC controls virulence in the plant pathogen Fusarium oxysporum.Mol Microbiol. 2003 May;48(3):765-79. doi: 10.1046/j.1365-2958.2003.03465.x. Mol Microbiol. 2003. PMID: 12694620
-
Ambient pH sensing in filamentous fungi: pitfalls in elucidating regulatory hierarchical signaling networks.IUBMB Life. 2013 Nov;65(11):930-5. doi: 10.1002/iub.1217. Epub 2013 Oct 30. IUBMB Life. 2013. PMID: 24265200
-
Ambient pH gene regulation in fungi: making connections.Trends Microbiol. 2008 Jun;16(6):291-300. doi: 10.1016/j.tim.2008.03.006. Epub 2008 May 3. Trends Microbiol. 2008. PMID: 18457952 Review.
Cited by
-
Comparative transcriptome analysis of genes and metabolic pathways involved in sporulation in Ganoderma lingzhi.G3 (Bethesda). 2022 Mar 4;12(3):jkab448. doi: 10.1093/g3journal/jkab448. G3 (Bethesda). 2022. PMID: 35079793 Free PMC article.
-
The Arrestin-like Protein palF Contributes to Growth, Sporulation, Spore Germination, Osmolarity, and Pathogenicity of Coniella vitis.J Fungi (Basel). 2024 Jul 22;10(7):508. doi: 10.3390/jof10070508. J Fungi (Basel). 2024. PMID: 39057393 Free PMC article.
-
Methods for studying microbial acid stress responses: from molecules to populations.FEMS Microbiol Rev. 2024 Sep 18;48(5):fuae015. doi: 10.1093/femsre/fuae015. FEMS Microbiol Rev. 2024. PMID: 38760882 Free PMC article. Review.
-
Genome-Wide Identification and Functional Analysis of the bZIP Transcription Factor Family in Rice Bakanae Disease Pathogen, Fusarium fujikuroi.Int J Mol Sci. 2022 Jun 15;23(12):6658. doi: 10.3390/ijms23126658. Int J Mol Sci. 2022. PMID: 35743103 Free PMC article.
-
VmPacC-mediated pH regulation of Valsa mali confers to host acidification identified by comparative proteomics analysis.Stress Biol. 2023 Jun 21;3(1):18. doi: 10.1007/s44154-023-00097-y. Stress Biol. 2023. PMID: 37676527 Free PMC article.
References
-
- Li BQ, Wang WH, Zong YY, Qin GZ & Tian SP (2012) Exploring pathogenic mechanisms of Botrytis cinerea secretome under different ambient pH based on comparative proteomic analysis. J Proteome Res 11, 4249-4260.
-
- Li BQ, Lai TF, Qin GZ & Tian SP (2010) Ambient pH stress inhibits spore germination of Penicillium expansum by impairing protein synthesis and folding: a proteomic-based study. J Proteome Res 9, 298-307.
-
- Selvig K & Alspaugh JA (2011) pH response pathways in fungi: adapting to host-derived and environmental signals. Mycobiology 39, 249-256.
-
- Franco-Frias E, Ruiz-Herrera J & Arechiga-Carvajal ET (2014) Transcriptomic analysis of the role of Rim101/PacC in the adaptation of Ustilago maydis to an alkaline environment. Microbiology 160, 1985-1998.
-
- Hu Y, Lian L, Xia J, Hu S, Xu W, Zhu J, Ren A, Shi L & Zhao MW (2019) Influence of PacC on the environmental stress adaptability and cell wall components of Ganoderma lucidum. Microbiol Res 230, 126348.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources