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Comparative Study
. 1988 Jun;85(11):4005-9.
doi: 10.1073/pnas.85.11.4005.

Nature of polymorphism in HLA-A, -B, and -C molecules

P Parham  1 , C E Lomen, D A Lawlor, J P Ways, N Holmes, H L Coppin, R D Salter, A M Wan, P D Ennis
Affiliations
Comparative Study

Nature of polymorphism in HLA-A, -B, and -C molecules

P Parham et al. Proc Natl Acad Sci U S A. 1988 Jun.

Abstract

Diversity in 39 HLA-A, -B, and -C molecules is derived from 20 amino acid positions of high variability and 71 positions of low variability. Variation in the structurally homologous alpha 1 and alpha 2 domains is distinct and may correlate with partial segregation of peptide and T-cell receptor binding functions. Comparison of 15 HLA-A with 20 HLA-B molecules reveals considerable locus-specific character, due primarily to differences at polymorphic residues. The results indicate that genetic exchange between alleles of the same locus has been a more important mechanism in the generation of HLA-A, -B, and -C diversity than genetic exchange events between alleles of different loci.

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