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Review
. 2021 Apr;37(2):251-266.
doi: 10.1016/j.ccc.2020.11.001.

Defining Acute Kidney Injury

Siddharth Verma  1 , John A Kellum  2
Affiliations
Review

Defining Acute Kidney Injury

Siddharth Verma et al. Crit Care Clin. 2021 Apr.

Abstract

Acute kidney injury (AKI) is a syndrome of impaired kidney function associated with reduced survival and increased morbidity. International consensus criteria were developed based on changes in serum creatinine and urine output. Based on these definitions, epidemiologic studies have shown strong associations with clinical outcomes including death and dialysis. However, numerous limitations exist for creatinine and urine volume as markers of AKI and novel biomarkers have been developed to detect cellular stress or damage. Persistent AKI and acute kidney disease are relatively new concepts that explore the idea of AKI as a continuum with chronic kidney disease.

Keywords: Acute kidney disease; Acute kidney injury; Biomarkers; Electronic alerts.

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Conflict of interest statement

Disclosure J.A. Kellum discloses consulting fees and grant support from Astute Medical/BioMerieux; S. Verma has no disclosures.

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