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Editorial
. 2021 Jun;160(7):2251-2254.
doi: 10.1053/j.gastro.2021.03.029. Epub 2021 Mar 19.

COVID-19 Gastrointestinal Symptoms and Attenuation of the Immune Response to SARS-CoV-2

Jonathan Miller  1 , Kelley S Yan  2
Affiliations
Editorial

COVID-19 Gastrointestinal Symptoms and Attenuation of the Immune Response to SARS-CoV-2

Jonathan Miller et al. Gastroenterology. 2021 Jun.
No abstract available

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Figures

Figure 1
Figure 1
Patients with COVID-19 and gastrointestinal (GI) symptoms exhibit an attenuated immune response. (A) Schematic of workflow adapted from Livanos et al. Endoscopic biopsies from infected and noninfected patients were analyzed histologically, homogenized to inoculate Vero E6 cells in culture, and were analyzed by mass cytometry. Large clinical cohorts demonstrated improved survival in patients with GI symptoms. (B) The cellular, transcriptomic, and proteomic changes observed in patients with COVID-19 with GI manifestations correlated with clinical observations of decreased severity and improved survival. EC, epithelial compartment; LP, lamina propria.
See this image and copyright information in PMC

Comment on

  • Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms.
    Livanos AE, Jha D, Cossarini F, Gonzalez-Reiche AS, Tokuyama M, Aydillo T, Parigi TL, Ladinsky MS, Ramos I, Dunleavy K, Lee B, Dixon RE, Chen ST, Martinez-Delgado G, Nagula S, Bruce EA, Ko HM, Glicksberg BS, Nadkarni G, Pujadas E, Reidy J, Naymagon S, Grinspan A, Ahmad J, Tankelevich M, Bram Y, Gordon R, Sharma K, Houldsworth J, Britton GJ, Chen-Liaw A, Spindler MP, Plitt T, Wang P, Cerutti A, Faith JJ, Colombel JF, Kenigsberg E, Argmann C, Merad M, Gnjatic S, Harpaz N, Danese S, Cordon-Cardo C, Rahman A, Schwartz RE, Kumta NA, Aghemo A, Bjorkman PJ, Petralia F, van Bakel H, Garcia-Sastre A, Mehandru S. Livanos AE, et al. Gastroenterology. 2021 Jun;160(7):2435-2450.e34. doi: 10.1053/j.gastro.2021.02.056. Epub 2021 Mar 4. Gastroenterology. 2021. PMID: 33676971 Free PMC article.

References

    1. Gupta A., Madhavan M.V., Sehgal K., et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26:1017–1032. - PMC - PubMed
    1. Xiao F., Tang M., Zheng X., et al. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology. 2020;158:1831–1833.e3. - PMC - PubMed
    1. Wang W., Xu Y., Gao R., et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020;323:1843–1844. - PMC - PubMed
    1. Cheung K.S., Hung I.F.N., Chan P.P.Y., et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: systematic review and meta-analysis. Gastroenterology. 2020;159:81–95. - PMC - PubMed
    1. Lee J.J., Kopetz S., Vilar E., et al. Relative abundance of SARS-CoV-2 entry genes in the enterocytes of the lower gastrointestinal tract. Genes (Basel) 2020:11. - PMC - PubMed