Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May;35(3):1480-1486.
doi: 10.1111/jvim.16086. Epub 2021 Mar 23.

CyberKnife stereotactic radiotherapy for treatment of primary intracranial tumors in dogs

Gabrielle L Carter  1 , Gregory K Ogilvie  1   2 , Lenore A Mohammadian  1 , Phillip J Bergman  3 , Rachel P Lee  1 , David R Proulx  1
Affiliations

CyberKnife stereotactic radiotherapy for treatment of primary intracranial tumors in dogs

Gabrielle L Carter et al. J Vet Intern Med. 2021 May.

Abstract

Background: Limited data exist about the use, efficacy, and prognostic factors influencing outcome when CyberKnife is used to treat dogs with intracranial neoplasia.

Objectives: To determine the prognosis and associated prognostic factors for dogs that were imaged, determined to have primary intracranial tumors, and treated with CyberKnife radiotherapy.

Animals: Fifty-nine dogs treated with CyberKnife radiotherapy for primary intracranial tumors.

Methods: Retrospective medical record review of cases from January 2010 to June 2016. Data extracted from medical records included signalment, weight, seizure history, tumor location, tumor type (based on imaging), gross tumor volume, planned tumor volume, treatment dates, radiation dose, recurrence, date of death, and cause of death.

Results: The median progression-free interval (PFI) was 347 days (range 47 to 1529 days), and the median survival time (MST) was 738 days (range 4 to 2079 days). Tumor location was significantly associated with PFI when comparing cerebrum (median PFI 357 days; range 47-1529 days) versus cerebellum (median PFI 97 days; range 97-168 days) versus brainstem (median PFI 266 days; range 30-1484 days), P = .03. Additionally, the presumed tumor type was significantly associated with MST (P < .001).

Conclusions and clinical importance: Use of Cyberknife and SRT might improve MST, compared with RT, in dogs with intracranial neoplasia.

Keywords: brain; cancer; dog; radiation.

PubMed Disclaimer

Conflict of interest statement

Authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Kaplan‐Meier progression‐free interval plot for dogs with intracranial neoplasia treated with CyberKnife radiation therapy. Kaplan‐Meier overall median progression‐free interval was 347 days. The dots represent censored dogs
FIGURE 2
FIGURE 2
Kaplan‐Meier progression‐free interval plot for dogs with cerebral, cerebellar, and brainstem neoplasia treated with CyberKnife radiation therapy. The dots represent censored dogs
FIGURE 3
FIGURE 3
Kaplan‐Meier survival plot for dogs with intracranial neoplasia treated with CyberKnife radiation therapy. Kaplan‐Meier overall median survival time was 738 days. The dots represent censored dogs
FIGURE 4
FIGURE 4
Kaplan‐Meier survival plot for dogs with meningiomas and those with other tumor types treated with CyberKnife radiation therapy. The dots represent censored dogs
See this image and copyright information in PMC

References

    1. Rossmeisl JH, Pancotto TE. Tumors of the nervous system. In: Vail DM, Thamm DH, Liptak JM, eds. Withrow & MacEwens Small Animal Clinical Oncology. 6th ed. St. Louis, MO: Elsevier; 2020:657‐665.
    1. Treggiari E, Maddox TW, Goncalves R, et al. Retrospective comparison of three‐dimensional conformal radiation therapy vs. prednisolone alone in 30 cases of canine infratentorial brain tumors. Vet Radiol Ultrasound. 2016;58(1):106‐116. - PubMed
    1. Snyder JM, Shofer FS, Winkle TJV, et al. Canine intracranial primary neoplasia: 173 cases (1986–2003). J Vet Intern Med. 2006;20(3):669‐675. - PubMed
    1. Griffen L, Nolan M, Selmic L, et al. Stereotactic radiation therapy for treatment of canine intracranial meningiomas. Vet Comp Oncol. 2014;14(4):e158‐e170. - PubMed
    1. Keyerlerber MA, McEntee MC, Farrelly J, et al. Three‐dimensional conformal radiation therapy alone or in combination with surgery for treatment of canine intracranial meningiomas. Vet Comp Oncol. 2013;13(4):385‐397. - PubMed

LinkOut - more resources