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Review
. 2021 Aug;30(8):1156-1166.
doi: 10.1111/exd.14332. Epub 2021 Apr 5.

Dysregulated epigenetic modifications in psoriasis

Chang Zeng  1 , Lam C Tsoi  1   2 , Johann E Gudjonsson  1   3
Affiliations
Free article
Review

Dysregulated epigenetic modifications in psoriasis

Chang Zeng et al. Exp Dermatol. 2021 Aug.
Free article

Abstract

The observed incidence of psoriasis has been gradually increasing over time (J Am Acad Dermatol, 03, 2009, 394), but the underlying pathogenic factors have remained unclear. Recent studies suggest the importance of epigenetic modification in the pathogenesis of psoriasis. Aberrant epigenetic patterns including changes in DNA methylation, histone modifications and non-coding RNA expression are observed in psoriatic skin. Reversing these epigenetic mechanisms has showed improvement in psoriatic phenotypes, making epigenetic therapy a potential avenue for psoriasis treatment. Here, we summarize relevant evidence for epigenetic dysregulation contributing to psoriasis susceptibility and pathogenesis, and the factors responsible for epigenetic modifications, providing directions for potential future clinical avenues.

Keywords: DNA methylation; epigenetics; histone modification; non-coding RNA; psoriasis.

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References

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