Antibody response to a single dose of SARS-CoV-2 mRNA vaccine in patients with rheumatic and musculoskeletal diseases

Brian J Boyarsky¹, Jake A Ruddy¹, Caoilfhionn M Connolly², Michael T Ou¹, William A Werbel³, Jacqueline M Garonzik-Wang¹, Dorry L Segev^{4

5}, Julie J Paik²

Affiliations

¹ Surgery, Johns Hopkins University, Baltimore, Maryland, USA.
² Rheumatology, Johns Hopkins Unveristy, Baltimore, Maryland, USA.
³ Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA.
⁴ Surgery, Johns Hopkins University, Baltimore, Maryland, USA dorry@jhmi.edu.
⁵ Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

PMID: 33757968
PMCID: PMC8822300
DOI: 10.1136/annrheumdis-2021-220289

Antibody response to a single dose of SARS-CoV-2 mRNA vaccine in patients with rheumatic and musculoskeletal diseases

Brian J Boyarsky et al. Ann Rheum Dis. 2021 Aug.

. 2021 Aug;80(8):1098-1099.

doi: 10.1136/annrheumdis-2021-220289. Epub 2021 Mar 23.

Authors

Brian J Boyarsky¹, Jake A Ruddy¹, Caoilfhionn M Connolly², Michael T Ou¹, William A Werbel³, Jacqueline M Garonzik-Wang¹, Dorry L Segev^{4

5}, Julie J Paik²

Affiliations

¹ Surgery, Johns Hopkins University, Baltimore, Maryland, USA.
² Rheumatology, Johns Hopkins Unveristy, Baltimore, Maryland, USA.
³ Infectious Diseases, Johns Hopkins University, Baltimore, Maryland, USA.
⁴ Surgery, Johns Hopkins University, Baltimore, Maryland, USA dorry@jhmi.edu.
⁵ Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

PMID: 33757968
PMCID: PMC8822300
DOI: 10.1136/annrheumdis-2021-220289

No abstract available

Keywords: COVID-19; antirheumatic agents; autoimmune diseases; vaccination.

PubMed Disclaimer

Conflict of interest statement

Competing interests: DLS has the following financial disclosures: consulting and speaking honoraria from Sanofi, Novartis, CSL Behring, Jazz Pharmaceuticals, Veloxis, Mallincrodt and Thermo Fisher Scientific.

Comment in

Covid vaccination in patients with autoimmune diseases treated with mycophenolate: Let's think back to the recommendations.
Benucci M, Infantino M, Manfredi M, Li Gobbi F, Sarzi-Puttini P, Caproni M. Benucci M, et al. Autoimmun Rev. 2021 Oct;20(10):102908. doi: 10.1016/j.autrev.2021.102908. Epub 2021 Jul 16. Autoimmun Rev. 2021. PMID: 34274547 Free PMC article. No abstract available.

References

1. Higgins V, Fabros A, Kulasingam V. Quantitative measurement of anti-SARS-CoV-2 antibodies: Analytical and clinical evaluation. J Clin Microbiol. 2021. Jan 22. - PMC - PubMed
1. Bingham CO 3rd, Looney RJ, Deodhar A, Halsey N, Greenwald M, Codding C, et al. Immunization responses in rheumatoid arthritis patients treated with rituximab: results from a controlled clinical trial. Arthritis Rheum. 2010. Jan; 62(1):64–74. - PubMed
1. Park JK, Lee YJ, Shin K, Ha YJ, Lee EY, Song YW, et al. Impact of temporary methotrexate discontinuation for 2 weeks on immunogenicity of seasonal influenza vaccination in patients with rheumatoid arthritis: a randomised clinical trial. Ann Rheum Dis. 2018. Jun; 77(6):898–904. - PMC - PubMed
1. McMahan ZH, Bingham CO 3rd., Effects of biological and non-biological immunomodulatory therapies on the immunogenicity of vaccines in patients with rheumatic diseases. Arthritis Res Ther. 2014. Dec 23; 16(6):506. - PMC - PubMed
1. Felten R, Dubois M, Ugarte-Gil MF, Chaudier A, Kawka L, Bergier H, et al. Vaccination against COVID-19: Expectations and concerns of patients with autoimmune and rheumatic diseases. Lancet Rheumatology 2021. - PMC - PubMed

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Antibody response to a single dose of SARS-CoV-2 mRNA vaccine in patients with rheumatic and musculoskeletal diseases

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Antibody response to a single dose of SARS-CoV-2 mRNA vaccine in patients with rheumatic and musculoskeletal diseases

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