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Comparative Study
. 2021 Oct 1;40(10):1316-1321.
doi: 10.1097/ICO.0000000000002690.

Patient-Reported Outcomes After Corneal Transplantation

Grace E Dunbar  1 , Michael Titus  2 , Joshua D Stein  1   3 , Tomas E Meijome  1 , Shahzad I Mian  1 , Maria A Woodward  1   3   4
Affiliations
Comparative Study

Patient-Reported Outcomes After Corneal Transplantation

Grace E Dunbar et al. Cornea. .

Abstract

Purpose: To characterize vision-related quality of life after penetrating keratoplasty (PKP), deep anterior lamellar keratoplasty (DALK), Descemet stripping automated endothelial keratoplasty (DSAEK), and Descemet membrane endothelial keratoplasty (DMEK) using the National Eye Institute Visual Function Questionnaire (NEI-VFQ 9).

Methods: Using the Sight Outcomes Research Collaborative ophthalmology electronic health record repository, questionnaire responses were obtained from 103 PKP patients, 24 DALK patients, 42 DSAEK patients, and 50 DMEK patients undergoing postoperative examination. No exclusions were made based on preoperative diagnosis, age, complications, or comorbidities. Associations between clinical characteristics and vision-related quality of life were analyzed using nonparametric and linear regression methods.

Results: Patients were surveyed an average of 1.5 years postoperatively (range 24 d to 4.4 yrs). Participants who had undergone DALK, DMEK, DSAEK, and PKP had median composite VFQ scores of 77.8, 84.2, 76.1, and 70.6, respectively (P= 0.002). There were no significant differences in VFQ scores between patients treated with DMEK versus DSAEK (P = 0.440) or between patients treated with PKP versus DALK (P = 1.000). Higher postoperative acuities in the operative and fellow eyes were associated with higher VFQ scores (P < 0.001 and P < 0.001). When controlling for postoperative acuity by regression modeling, surgery type was not associated with patient-reported composite VFQ scores.

Conclusions: In this study, patient-reported vision-related quality of life was similar among DMEK and DSAEK participants and also among DALK and PKP participants. When controlling for postoperative acuity, vision-related quality of life was similar among all study participants, irrespective of the keratoplasty technique.

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Conflict of interest statement

G. E. Dunbar reported receiving a grant from Eversight. M. A. Woodward reported receiving grants from National Institutes of Health (NIH-1R01EY031033) and the Michigan Institute for Clinical & Health Research (MICHR). The remaining authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Distribution of the composite National Eye Institute Visual Function Questionnaire (NEI-VFQ 9) Scores across participants
See this image and copyright information in PMC

References

    1. Denniston AK, Kyte D, Calvert M, et al.An introduction to patient-reported outcome measures in ophthalmic research. Eye. 2014;28:637–645. 10.1038/eye.2014.41. - DOI - PMC - PubMed
    1. Dean S, Mathers JM, Calvert M, et al.“The patient is speaking”: Discovering the patient voice in ophthalmology. Br J Ophthalmol. 2017;101:700–708. 10.1136/bjophthalmol-2016-309955. - DOI - PMC - PubMed
    1. Braithwaite T, Calvert M, Gray A, et al.The use of patient-reported outcome research in modern ophthalmology: impact on clinical trials and routine clinical practice. Patient Relat Outcome Meas. 2019;Volume 10:9–24. 10.2147/prom.s162802. - DOI - PMC - PubMed
    1. Mangione CM, Berry S, Spritzer K, et al.Identifying the content area for the 51-item National Eye Institute Visual Function Questionnaire: results from focus groups with visually impaired persons. Arch Ophthalmol. 1998;116:227–233. - PubMed
    1. Mangione CM. Development of the 25-item National Eye Institute Visual Function Questionnaire. Arch Ophthalmol. 2001;119:1050–1058. - PubMed

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