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. 2021 Mar 23;7(1):17.
doi: 10.1038/s41421-021-00249-2.

SARS-CoV-2 cell tropism and multiorgan infection

Jia Liu #  1   2 , Yufeng Li #  2 , Qian Liu #  1 , Qun Yao #  3 , Xi Wang  2 , Huanyu Zhang  2 , Rong Chen  3 , Liang Ren  1 , Juan Min  2 , Fei Deng  2 , Bing Yan  2 , Liang Liu  1 , Zhihong Hu  4 , Manli Wang  5 , Yiwu Zhou  6
Affiliations

SARS-CoV-2 cell tropism and multiorgan infection

Jia Liu et al. Cell Discov. .
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Detection of multiorgan infection and cell tropism of SARS-CoV-2 in postmortem samples.
a Co-localization analysis of SARS-CoV-2 (spike proteins, red) and ACE2 (green) in the lung (i), trachea (ii), small intestine (iii), and kidney (iv) via dual-immunofluorescent staining. b Characterization of SARS-CoV-2-positive cell tropism in the lung. Co-localization of SARS-CoV-2 (spike proteins, red) with cell type-specific markers (green) was determined via multiplex-immunofluorescence staining. KRT5 (ii), Ac-Tub (iii), CC10 (iv), MUC5A (v), RAGE (vii), and SFTPC (viii) were used for basal, ciliated, club, goblet, AT1, and AT2 cells, respectively. The corresponding hematoxylin and eosin staining figures were shown in (i) and (vi), respectively. c Characterization of SARS-CoV-2 positive cell types in the trachea (i and ii), small intestine (iii), and kidney (iv). TFF1 was used for goblet cells (i), and Ac-Tub for ciliated cells (ii) in the trachea; β-catenin was used for epithelial cells in small intestine (iii) and kidney (iv). White arrows (iii) indicate the mucosa of the small intestine. d Co-localization analysis of SARS-CoV-2 (spike proteins, red) with CD31+ vascular endothelial cells (green) in the lung (i), trachea (ii), small intestine (iii), and kidney (iv). e Schematic of SARS-CoV-2 multiorgan infection and cell tropism in the human body.
See this image and copyright information in PMC

References

    1. Zhou P, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579:270–273. doi: 10.1038/s41586-020-2012-7. - DOI - PMC - PubMed
    1. Hou YJ, et al. SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract. Cell. 2020;182:429–446.e14. doi: 10.1016/j.cell.2020.05.042. - DOI - PMC - PubMed
    1. Ziegler CGK, et al. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell. 2020;181:1016–1035 e1019. doi: 10.1016/j.cell.2020.04.035. - DOI - PMC - PubMed
    1. Fang Y, et al. Distinct stem/progenitor cells proliferate to regenerate the trachea, intrapulmonary airways and alveoli in COVID-19 patients. Cell Res. 2020;30:705–707. doi: 10.1038/s41422-020-0367-9. - DOI - PMC - PubMed
    1. Xiao F, et al. Evidence for Gastrointestinal Infection of SARS-CoV-2. Gastroenterology. 2020;158:1831–1833.e3. doi: 10.1053/j.gastro.2020.02.055. - DOI - PMC - PubMed

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