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[Preprint]. 2021 Mar 12:2021.03.11.21253421.
doi: 10.1101/2021.03.11.21253421.

Exposure to SARS-CoV-2 within the household is associated with greater symptom severity and stronger antibody responses in a community-based sample of seropositive adults

Joshua M Schrock  1   2   3 , Daniel T Ryan  1   2 , Rana Saber  1   2 , Nanette Benbow  4 , Lauren A Vaught  5   6 , Nina Reiser  5   6 , Matthew P Velez  5   6 , Ryan Hsieh  5   6 , Michael Newcomb  1   2 , Alexis R Demonbreun  5   7 , Brian Mustanski  1   2 , Elizabeth M McNally  5   6   8 , Richard D'Aquila  9 , Thomas W McDade  3   10
Affiliations

Exposure to SARS-CoV-2 within the household is associated with greater symptom severity and stronger antibody responses in a community-based sample of seropositive adults

Joshua M Schrock et al. medRxiv. .

Update in

Abstract

Magnitude of SARS-CoV-2 virus exposure may contribute to symptom severity. In a sample of seropositive adults (n=1101), we found that individuals who lived with a known COVID-19 case exhibited greater symptom severity and IgG concentrations compared to individuals who were seropositive but did not live with a known case (P<0.0001).

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Figures

Figure 1.
Figure 1.. Associations between exposure to a cohabitant with Covid-19, symptom severity scores, and SARS-CoV-2 antibody concentrations.
The y-axis for SARS-CoV-2 IgG concentrations is presented on a log2 scale. Data are from a community-based sample of seropositive adults from the Chicago area (n=1011). The distribution for each category is represented by smoothed kernel density plots overlaid with boxplots depicting interquartile ranges. This figure was created using the R package “ggplot2” (version 3.3.2).
See this image and copyright information in PMC

References

    1. Brodin P. Immune determinants of COVID-19 disease presentation and severity. Nat Med. 2021;27(1):28–33. - PubMed
    1. Demonbreun AR, McDade TW, Pesce L, et al. Patterns and persistence of SARS-CoV-2 IgG antibodies in a US metropolitan site. medRxiv. 2020. - PMC - PubMed
    1. Guallar MP, Meirino R, Donat-Vargas C, Corral O, Jouve N, Soriano V. Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity. Int J Infect Dis. 2020;97:290–292. - PMC - PubMed
    1. Imai M, Iwatsuki-Horimoto K, Hatta M, et al. Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development. Proc Natl Acad Sci U S A. 2020;117(28):16587–16595. - PMC - PubMed
    1. Van Damme W, Dahake R, van de Pas R, Vanham G, Assefa Y. COVID-19: Does the infectious inoculum dose-response relationship contribute to understanding heterogeneity in disease severity and transmission dynamics? Med Hypotheses. 2021;146:110431. - PMC - PubMed

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