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Review
. 2021 Feb;35(1):99-109.
doi: 10.1016/j.hoc.2020.08.013. Epub 2020 Oct 26.

Immune Checkpoint Therapies for Melanoma

Elizabeth I Buchbinder  1
Affiliations
Review

Immune Checkpoint Therapies for Melanoma

Elizabeth I Buchbinder. Hematol Oncol Clin North Am. 2021 Feb.

Abstract

Immunotherapy with immune checkpoint inhibition has dramatically changed the treatment of melanoma. Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 are approved for the treatment of advanced melanoma alone and in combination. In addition, these agents are approved for use in high-risk resected stage III melanoma in the adjuvant setting. Clinical trials testing the combination of immune checkpoint inhibition with other therapies and novel immunotherapies continue. This article reviews the current literature on approved uses of immune checkpoint inhibition in melanoma and discusses ongoing trials and future directions.

Keywords: Immune checkpoint inhibition; Immunotherapy; Melanoma.

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Conflict of interest statement

Disclosure Dr E.I. Buchbinder received compensation for consulting from BMS, Trieza, Novartis, and Partner Therapeutics. She receives clinical trial support form Eli Lilly, Novartis, BMS, Genentech, and BVD.

MeSH terms