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Case Reports
. 2021 Mar 22:54:e0633-2020.
doi: 10.1590/0037-8682-0633-2020. eCollection 2021.

Treatment of tegumentary leishmaniasis in two hemodialysis patients with end-stage renal disease using two series of pentamidine

Karla Cristina Petruccelli  1   2 , Kátia Nascimento Couceiro  1   3 , Maria das Graças Vale Barbosa Guerra  1   3   4 , Zanair Soares Vasconcelos  1   5 , Alba Regina Jorge Brandão  2 , Monica Hosannah Silva E Silva  1   6 , Jorge Augusto de Oliveira Guerra  1   4   6
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Case Reports

Treatment of tegumentary leishmaniasis in two hemodialysis patients with end-stage renal disease using two series of pentamidine

Karla Cristina Petruccelli et al. Rev Soc Bras Med Trop. .

Abstract

In this study, we present two cases of cutaneous leishmaniasis in patients with end-stage renal disease, who were treated solely with intramuscular pentamidine. In such cases, treatment implies a fine line between therapeutic efficacy and toxicity. This is suggestive of a knowledge gap; however, findings indicate that this is still the fastest and safest alternative to the treatment with antimonials. Also, it can help avoid the side effects that occur upon using antimonials.

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Conflict of interest statement

Conflict of Interest: We declare no competing interests.

Figures

FIGURE 1:
FIGURE 1:. Features of lesions in two cases of American cutaneous leishmaniasis in hemodialysis patients with ESRD. (A) Upper limb lesion, 4 cm in diameter. (B) Healed upper limb lesion after six months of treatment. (C) Ulcerated upper limb lesion, 3 cm in diameter.
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