Transplantation From Older Donors: Can Senolytics Turn Back the Clock?
- PMID: 33760787
- DOI: 10.1097/TP.0000000000003538
Transplantation From Older Donors: Can Senolytics Turn Back the Clock?
Comment on
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Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.Nat Commun. 2020 Aug 27;11(1):4289. doi: 10.1038/s41467-020-18039-x. Nat Commun. 2020. PMID: 32855397 Free PMC article.
References
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- Dayoub JC, Cortese F, Anžič A, et al. The effects of donor age on organ transplants: a review and implications for aging research. Exp Gerontol. 2018; 110:230–240
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- Iske J, Seyda M, Heinbokel T, et al. Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation. Nat Commun. 2020; 11:4289
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- Rao PS, Schaubel DE, Guidinger MK, et al. A comprehensive risk quantification score for deceased donor kidneys: the kidney donor risk index. Transplantation. 2009; 88:231–236
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- Feng S, Goodrich NP, Bragg-Gresham JL, et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant. 2006; 6:783–790
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- Klassen DK, Edwards LB, Stewart DE, et al. The OPTN deceased donor potential study: implications for policy and practice. Am J Transplant. 2016; 16:1707–1714
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