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. 2021 Jul 15;204(2):142-148.
doi: 10.1164/rccm.202011-4239PP.

Latent Tuberculosis: Two Centuries of Confusion

Marcel A Behr  1   2 , Eva Kaufmann  1   3 , Jacalyn Duffin  4 , Paul H Edelstein  5   6 , Lalita Ramakrishnan  6
Affiliations

Latent Tuberculosis: Two Centuries of Confusion

Marcel A Behr et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Publications on TB (left y-axis) and latent TB (right y-axis). TB = tuberculosis.
Figure 2.
Figure 2.
Shifting definitions of latent tuberculosis over time. Both pathology and microbiology positivity were ascertained postmortem. Immunologic testing is done antemortem. ATS = American Thoracic Society.
Figure 3.
Figure 3.
Mycobacterium tuberculosis infection from different vantages. Tuberculous reactivity starts later than infection because of the time to mount a measurable immune response and is presented as earlier to become negative to represent waning responses with severe infection. *NS denotes nonspecific. IGRA = IFN-γ release assay; TST = tuberculin skin test.
See this image and copyright information in PMC

References

    1. World Health Organization. Global tuberculosis report 2020. Geneva, Switzerland: World Health Organization; 2020.
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    1. Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC. Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA . 1999;282:677–686. - PubMed
    1. Sudre P, ten Dam G, Kochi A. Tuberculosis: a global overview of the situation today. Bull World Health Organ . 1992;70:149–159. - PMC - PubMed
    1. Behr MA, Edelstein PH, Ramakrishnan L. Is Mycobacterium tuberculosis infection life long? BMJ . 2019;367:l5770. - PMC - PubMed

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