Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 26;100(12):e25241.
doi: 10.1097/MD.0000000000025241.

The efficacy of combined music therapy and Tai Chi for major depressive disorder: Study protocol for a randomized controlled trial

Huixian Xie  1 , Yiping Tang  2 , Fengmin Cheng  1 , Jucai Chu  1
Affiliations

The efficacy of combined music therapy and Tai Chi for major depressive disorder: Study protocol for a randomized controlled trial

Huixian Xie et al. Medicine (Baltimore). .

Expression of concern in

  • Expression of Concern: Study Protocols.
    [No authors listed] [No authors listed] Medicine (Baltimore). 2025 Nov 7;104(45):e46330. doi: 10.1097/MD.0000000000046330. Medicine (Baltimore). 2025. PMID: 41204616 Free PMC article. No abstract available.

Abstract

Background: There are no clinical trials evaluating the efficacy of combined music and Tai Chi therapy for patients with major depression. Therefore, the primary objective of the present study was to evaluate the efficacy of Tai Chi and music therapy on psychological status and quality of life among patients with major depressive disorder in China.

Methods: This work is a part of a comprehensive research project to assess and provide intervention that potentially improves psychological status and quality of life among patients with major depressive disorder. This research project has been received ethical approval from the Medical Research and Ethics Committee in Taizhou Second People's Hospital (no. tzey2020023). After the introductory briefing, the acceptance to take the presession questionnaire implied the participant's consent to participate in the study. Eligible participants are divided into 3 groups according to completely randomized design: combined group (music therapy + Tai Chi), music therapy alone group, and Tai Chi alone group. The analyses will be performed using SPSS 22.0.0 (SPSS Inc, Chicago, IL).

Results: This protocol will provide a reliable theoretical basis for the following research.

Conclusion: The sample came from a single health center. Therefore, the results cannot be generalized for the entire population.

Trial registration: This study protocol was registered in Research Registry (researchregistry6597).

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Consolidated standards of reporting trials (CONSORT) diagram of patient flow through the study.
See this image and copyright information in PMC

References

    1. Hundal Ø. Major depressive disorder viewed as a dysfunction in astroglial bioenergetics. Med Hypotheses 2007;68:370–7. - PubMed
    1. Inoue T, Kitagawa M, Tanaka T, et al. Depression and major depressive disorder in patients with Parkinson's disease. Mov Disord 2010;25:44–9. - PubMed
    1. Klein DN. Depressive personality in the relatives of outpatients with dysthymic disorder and episodic major depressive disorder and normal controls. J Affect Disord 1999;55:19–27. - PubMed
    1. Mrazek DA, Hornberger JC, Altar CA, et al. A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996–2013. Psychiatr Serv 2014;65:977–87. - PubMed
    1. Feng K, Shen CY, Ma XY, et al. Effects of music therapy on major depressive disorder: a study of prefrontal hemodynamic functions using fNIRS. Psychiatry Res 2019;275:86–93. - PubMed

Publication types