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Case Reports
. 2021 Feb 17:10:124.
doi: 10.12688/f1000research.51094.1. eCollection 2021.

Case Report: Ziprasidone induced neuroleptic malignant syndrome

Yub Raj Sedhai  1 , Alok Atreya  2 , Prabin Phuyal  3 , Soney Basnyat  4 , Sagar Pokhrel  5
Affiliations
Case Reports

Case Report: Ziprasidone induced neuroleptic malignant syndrome

Yub Raj Sedhai et al. F1000Res. .

Abstract

Neuroleptic malignant syndrome (NMS) is a well-recognized neurologic emergency. It presents with classic features including hyperthermia, autonomic instability, muscle hypertonia, and mental status changes. The syndrome is potentially fatal and is associated with significant morbidity due to complications such as rhabdomyolysis, acute kidney injury, and ventricular arrhythmias due to the trans-cellular electrolyte shift. NMS is conventionally associated with the first-generation antipsychotic agents, however, has been described with the use of atypical and novel antipsychotics including Ziprasidone. A case of NMS with Ziprasidone use at the therapeutic dose is reported here.

Keywords: Neuroleptic Malignant Syndrome (NMS); Neurologic emergency; Parkinson’s disease; Ziprasidone.

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Conflict of interest statement

No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. ECG showing symmetrical T-wave inversions in leads V1 through V6 and QTc of 458 milliseconds.
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