The new COST Action European Venom Network (EUVEN)-synergy and future perspectives of modern venomics

Maria Vittoria Modica¹, Rafi Ahmad², Stuart Ainsworth³, Gregor Anderluh⁴, Agostinho Antunes^{5

6}, Dimitris Beis⁷, Figen Caliskan⁸, Mauro Dalla Serra⁹, Sebastien Dutertre¹⁰, Yehu Moran¹¹, Ayse Nalbantsoy¹², Naoual Oukkache¹³, Stano Pekar¹⁴, Maido Remm¹⁵, Bjoern Marcus von Reumont^{16

17}, Yiannis Sarigiannis¹⁸, Andrea Tarallo¹⁹, Jan Tytgat²⁰, Eivind Andreas Baste Undheim²¹, Yuri Utkin²², Aida Verdes^{23

24}, Aude Violette²⁵, Giulia Zancolli²⁶

Affiliations

¹ Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
² Department of Biotechnology, Inland Norway University of Applied Sciences, Holsetgata 22, 2318 Hamar, Norway.
³ Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, L3 5QA, Liverpool, UK.
⁴ National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.
⁵ CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Av. General Norton de Matos, 4450-208 Porto, Portugal.
⁶ Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal.
⁷ Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou St., 115 27 Athens, Greece.
⁸ Eskisehir Osmangazi University, Faculty of Science and Letters, Department of Biology, TR-26040 Eskisehir, Turkey.
⁹ Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via De Marini 6 - Torre di Francia, 16149 Genova, Italy.
¹⁰ IBMM, Université de Montpellier, CNRS, ENSCM, Place Eugene Bataillon, 34095 Montpellier, France.
¹¹ Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus - Givat Ram 9190401 Jerusalem, Israel.
¹² Ege University, Bioengineering Department, 180 Bornova, 35040 Izmir, Turkey.
¹³ Institut Pasteur of Morocco, 1 Place Louis Pasteur, 20100 Casablanca, Morocco.
¹⁴ Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlarska 2, 61137 Brno, Czechia.
¹⁵ Department of Bioinformatics, University of Tartu, IMCB, Riia 23, 51010, Tartu, Estonia.
¹⁶ Department of Insect Biotechnology, Justus Liebig University, Winchester Str. 2, 35394 Giessen, Germany.
¹⁷ LOEWE Center for Translational Biodiversity Genomics, Senckenberganlage 25 D-60325 Frankfurt/Main, Germany.
¹⁸ Department of Life and Health Sciences, University of Nicosia, 46 Makedonitissas Avenue, CY-2417 Nicosia, Cyprus.
¹⁹ Department of Research infrastructures for Marine Biological Resources, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
²⁰ Department of of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
²¹ Centre for Ecological and Evolutionary Synthesis,Department of Biosciences, University of Oslo, 1066 Blindern, 0316 Oslo, Norway.
²² Laboratory of Molecular Toxinology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya, 16/10, 117997 Moscow, Russian Federation.
²³ Department of Biodiversity and Evolutionary Biology, Museo Nacional de Ciencias Naturales, Consejo Superior de Investigaciones Científicas, Calle de José Gutiérrez Abascal 2, 28006 Madrid, Spain.
²⁴ Department of Life Science, Natural History Museum, Cromwell Rd, South Kensington, London SW7 5BD, UK.
²⁵ Alphabiotoxine Laboratory, B-7911 Montroeul-au-Bois, Belgium.
²⁶ Department of Ecology and Evolution, University of Lausanne, UNIL Sorge Le Biophore, CH - 1015 Lausanne, Switzerland.

PMID: 33764467
PMCID: PMC7992391
DOI: 10.1093/gigascience/giab019

The new COST Action European Venom Network (EUVEN)-synergy and future perspectives of modern venomics

Maria Vittoria Modica et al. Gigascience. 2021.

. 2021 Mar 25;10(3):giab019.

doi: 10.1093/gigascience/giab019.

Authors

Affiliations

¹ Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
² Department of Biotechnology, Inland Norway University of Applied Sciences, Holsetgata 22, 2318 Hamar, Norway.
³ Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, L3 5QA, Liverpool, UK.
⁴ National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.
⁵ CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Av. General Norton de Matos, 4450-208 Porto, Portugal.
⁶ Department of Biology, Faculty of Sciences, University of Porto, Rua do Campo Alegre, 4169-007 Porto, Portugal.
⁷ Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou St., 115 27 Athens, Greece.
⁸ Eskisehir Osmangazi University, Faculty of Science and Letters, Department of Biology, TR-26040 Eskisehir, Turkey.
⁹ Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via De Marini 6 - Torre di Francia, 16149 Genova, Italy.
¹⁰ IBMM, Université de Montpellier, CNRS, ENSCM, Place Eugene Bataillon, 34095 Montpellier, France.
¹¹ Department of Ecology, Evolution and Behavior, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus - Givat Ram 9190401 Jerusalem, Israel.
¹² Ege University, Bioengineering Department, 180 Bornova, 35040 Izmir, Turkey.
¹³ Institut Pasteur of Morocco, 1 Place Louis Pasteur, 20100 Casablanca, Morocco.
¹⁴ Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlarska 2, 61137 Brno, Czechia.
¹⁵ Department of Bioinformatics, University of Tartu, IMCB, Riia 23, 51010, Tartu, Estonia.
¹⁶ Department of Insect Biotechnology, Justus Liebig University, Winchester Str. 2, 35394 Giessen, Germany.
¹⁷ LOEWE Center for Translational Biodiversity Genomics, Senckenberganlage 25 D-60325 Frankfurt/Main, Germany.
¹⁸ Department of Life and Health Sciences, University of Nicosia, 46 Makedonitissas Avenue, CY-2417 Nicosia, Cyprus.
¹⁹ Department of Research infrastructures for Marine Biological Resources, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.
²⁰ Department of of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
²¹ Centre for Ecological and Evolutionary Synthesis,Department of Biosciences, University of Oslo, 1066 Blindern, 0316 Oslo, Norway.
²² Laboratory of Molecular Toxinology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya, 16/10, 117997 Moscow, Russian Federation.
²³ Department of Biodiversity and Evolutionary Biology, Museo Nacional de Ciencias Naturales, Consejo Superior de Investigaciones Científicas, Calle de José Gutiérrez Abascal 2, 28006 Madrid, Spain.
²⁴ Department of Life Science, Natural History Museum, Cromwell Rd, South Kensington, London SW7 5BD, UK.
²⁵ Alphabiotoxine Laboratory, B-7911 Montroeul-au-Bois, Belgium.
²⁶ Department of Ecology and Evolution, University of Lausanne, UNIL Sorge Le Biophore, CH - 1015 Lausanne, Switzerland.

PMID: 33764467
PMCID: PMC7992391
DOI: 10.1093/gigascience/giab019

Erratum in

Corrigendum to: The new COST Action European Venom Network (EUVEN)-synergy and future perspectives of modern venomics.
Modica MV, Ahmad R, Ainsworth S, Anderluh G, Antunes A, Beis D, Caliskan F, Serra MD, Dutertre S, Moran Y, Nalbantsoy A, Oukkache N, Pekar S, Remm M, von Reumont BM, Sarigiannis Y, Tarallo A, Tytgat J, Undheim EAB, Utkin Y, Verdes A, Violette A, Zancolli G. Modica MV, et al. Gigascience. 2021 Dec 29;10(12):giab102. doi: 10.1093/gigascience/giab102. Gigascience. 2021. PMID: 34966929 Free PMC article. No abstract available.

Abstract

Venom research is a highly multidisciplinary field that involves multiple subfields of biology, informatics, pharmacology, medicine, and other areas. These different research facets are often technologically challenging and pursued by different teams lacking connection with each other. This lack of coordination hampers the full development of venom investigation and applications. The COST Action CA19144-European Venom Network was recently launched to promote synergistic interactions among different stakeholders and foster venom research at the European level.

Keywords: COST; interdisciplinarity; networking; toxins; venom.

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Figures

**Figure 1:**
The multidisciplinary, integrative, and interconnected vision of venom research proposed in EUVEN. The centre is composed of modern morphology and -omics methods, in particular proteomics, transcriptomics, and genomics. In the surrounding white circle, main aspects of current venom research are indicated and summarized by the major topics in the dark grey ovals. These major topics are loosely associated with broader themes given in the light grey circle. The whole system is affected and interacts with outer drivers (purple). This integrative scheme is the heart of EUVEN, in which 5 major Working Groups focus on these topics and methods (top dark grey bar; see text for details). The cross subjects in which the scientific, technological, and socio-economic impact of EUVEN will be realized are outlined in the bottom dark grey bar.

**Figure 2:**
Number of indexed publications on venom between the years 2000 and 2020, comparing EU and extra-EU authors' contributions to venom research. The non-EU–authored publications doubled in the past 20 years. By contrast, the EU-only–authored ones only increased by ∼20%. The word “venom” wasted as query for “topic.” EU and non-EU countries were then excluded to obtain publication lists of extra-EU authors only and EU authors only, respectively (Source: Web of Science, last updated December 2020).

See this image and copyright information in PMC

References

1. Schendel V, Rash LD, Jenner RA, et al. . The diversity of venom: the importance of behavior and venom system morphology in understanding its ecology and evolution. Toxins (Basel). 2019;11(11):666. - PMC - PubMed
1. Casewell NR, Wüster W, Vonk FJ, et al. . Complex cocktails: the evolutionary novelty of venoms. Trends Ecol Evol. 2013;28(4):219–29. - PubMed
1. Fry BG, Roelants K, Champagne DE, et al. . The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms. Annu Rev Genom Hum Genet. 2009;10:483–511. - PubMed
1. Holford M, Daly M, King GF, et al. . Venoms to the rescue. Science. 2018;361(6405):842–4. - PubMed
1. Kim H, Park SY, Lee G. Potential therapeutic applications of bee venom on skin disease and its mechanisms: A literature review. Toxins (Basel). 2019;11:374. - PMC - PubMed

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The new COST Action European Venom Network (EUVEN)-synergy and future perspectives of modern venomics

Affiliations

The new COST Action European Venom Network (EUVEN)-synergy and future perspectives of modern venomics

Authors

Affiliations

Erratum in

Abstract

Figures

References

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LinkOut - more resources

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