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. 2021 Oct;29(10):5967-5972.
doi: 10.1007/s00520-021-06130-y. Epub 2021 Mar 25.

The effect of psychological condition before radiotherapy on prognosis in 390 patients initially treated for nasopharyngeal carcinoma

Jinmei Chen  1   2 , Yangjingling Hua  3 , Li Su  1   2 , Caihong Wang  3 , Hairong Zhang  3 , Jinru Ye  1 , Xiurong Song  1 , Rong Li  3 , Jun Tian  4 , Weijian Zhang  1 , Jinsheng Hong  5   6
Affiliations

The effect of psychological condition before radiotherapy on prognosis in 390 patients initially treated for nasopharyngeal carcinoma

Jinmei Chen et al. Support Care Cancer. 2021 Oct.

Abstract

Purpose: To explore whether anxiety and depression are prognostic indexes for overall survival in patients with nasopharyngeal carcinoma (NPC) who underwent intensity-modulated radiotherapy (IMRT).

Methods: Clinical data were collected for NPC patients who underwent IMRT. Anxiety and depression were investigated before radiotherapy by using the Hospital Anxiety and Depression Scale (HADS). The survival rate was calculated by the Kaplan-Meier method, and survival curves were compared among patients with different levels of anxiety and depression. The Cox risk regression model was used to screen the factors affecting survival.

Results: A total of 390 initially treated NPC patients were included in the study. Among them, 166 patients suffered from anxiety, and 95 patients suffered from depression before radiotherapy. The 5-year overall survival rates for patients with and without anxiety before radiotherapy were 71.6% and 81.8% (χ2 = 5.31, P = 0.021), respectively. The 5-year overall survival rates for patients with and without depression before radiotherapy were 74.3% and 78.1% (χ2 = 0.05, P = 0.82), respectively. Cox regression analysis indicated clinical stages (HR = 3.982, 95% CI: 2.365~6.705), anxiety (HR = 1.832, 95% CI: 1.140~2.944), and gender (HR = 0.555, 95% CI: 0.313~0.984) as independent prognostic factors.

Conclusion: Anxiety before radiotherapy is associated with poor prognosis in NPC patients.

Keywords: Anxiety; Depression; Nasopharyngeal carcinoma; Prognosis; Psychological condition; Survival.

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