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Review
. 2021:2283:1-14.
doi: 10.1007/978-1-0716-1302-3_1.

An Overview of Helicobacter pylori Infection

Rebecca FitzGerald  1 , Sinéad M Smith  2
Affiliations
Review

An Overview of Helicobacter pylori Infection

Rebecca FitzGerald et al. Methods Mol Biol. 2021.

Abstract

Helicobacter pylori (H. pylori) represents one of the most widespread bacterial infections globally. Infection causes chronic gastritis and increases the risk of peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The pioneering discovery of H. pylori by Marshall and Warren in the early 1980s has initiated fervent research into H. pylori as a pathogen ever since. This chapter aims to provide an overview of our understanding of H. pylori infection and its management, with a focus on current options for diagnosis, the challenges associated with H. pylori eradication, and the need for alternative therapeutic strategies based on furthering our understanding of host: H. pylori interactions.

Keywords: Antibiotic resistance; Bacteria; Diagnosis; Helicobacter pylori; Immune responses; Infection; Inflammation; Treatment; Vaccine; Virulence factor.

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References

    1. Salama NR, Hartung ML, Muller A (2013) Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol 11:385–399 - PubMed - PMC - DOI
    1. Fallone CA, Chiba N, van Zanten SV et al (2016) The Toronto consensus for the treatment of Helicobacter pylori infection in adults. Gastroenterology 151:51–69 - PubMed - DOI
    1. McColl KE (2010) Clinical practice. Helicobacter pylori infection. N Engl J Med 362:1597–1604 - PubMed - DOI
    1. Plummer M, Franceschi S, Vignat J et al (2015) Global burden of gastric cancer attributable to Helicobacter pylori. Int J Cancer 136:487–490 - PubMed - DOI
    1. Marshall B, Warren JR (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 323:1311–1315 - DOI

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