Vaccines and SARS-CoV-2 variants: the urgent need for a correlate of protection

doi:10.1016/S0140-6736(21)00468-2

Comment

. 2021 Apr 3;397(10281):1263-1264.

doi: 10.1016/S0140-6736(21)00468-2. Epub 2021 Mar 23.

Vaccines and SARS-CoV-2 variants: the urgent need for a correlate of protection

Salim S Abdool Karim¹

Affiliations

Affiliation

¹ Centre for the AIDS Programme of Research in South Africa, Durban 4013, South Africa; Department of Epidemiology, Columbia University, New York, USA. Electronic address: salim.abdoolkarim@caprisa.org.

PMID: 33765410
PMCID: PMC7984864
DOI: 10.1016/S0140-6736(21)00468-2

Comment

Vaccines and SARS-CoV-2 variants: the urgent need for a correlate of protection

Salim S Abdool Karim. Lancet. 2021.

. 2021 Apr 3;397(10281):1263-1264.

doi: 10.1016/S0140-6736(21)00468-2. Epub 2021 Mar 23.

Author

Salim S Abdool Karim¹

Affiliation

¹ Centre for the AIDS Programme of Research in South Africa, Durban 4013, South Africa; Department of Epidemiology, Columbia University, New York, USA. Electronic address: salim.abdoolkarim@caprisa.org.

PMID: 33765410
PMCID: PMC7984864
DOI: 10.1016/S0140-6736(21)00468-2

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Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Collins AM, Colin-Jones R, Cutland CL, Darton TC, Dheda K, Duncan CJA, Emary KRW, Ewer KJ, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Goodman AL, Green CM, Green CA, Heath PT, Hill C, Hill H, Hirsch I, Hodgson SHC, Izu A, Jackson S, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Lawrie AM, Lelliott A, Libri V, Lillie PJ, Mallory R, Mendes AVA, Milan EP, Minassian AM, McGregor A, Morrison H, Mujadidi YF, Nana A, O'Reilly PJ, Padayachee SD, Pittella A, Plested E, Pollock KM, Ramasamy MN, Rhead S, Schwarzbold AV, Singh N, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Tarrant R, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, Watson MEE, Williams CJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group. Voysey M, et al. Lancet. 2021 Jan 9;397(10269):99-111. doi: 10.1016/S0140-6736(20)32661-1. Epub 2020 Dec 8. Lancet. 2021. PMID: 33306989 Free PMC article. Clinical Trial.

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Matusali G, Sberna G, Meschi S, Gramigna G, Colavita F, Lapa D, Francalancia M, Bettini A, Capobianchi MR, Puro V, Castilletti C, Vaia F, Bordi L. Matusali G, et al. Viruses. 2022 Feb 2;14(2):312. doi: 10.3390/v14020312. Viruses. 2022. PMID: 35215903 Free PMC article.
Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 Replication by Hypertonic Saline Solution in Lung and Kidney Epithelial Cells.
Machado RRG, Glaser T, Araujo DB, Petiz LL, Oliveira DBL, Durigon GS, Leal AL, Pinho JRR, Ferreira LCS, Ulrich H, Durigon EL, Guzzo CR. Machado RRG, et al. ACS Pharmacol Transl Sci. 2021 Sep 3;4(5):1514-1527. doi: 10.1021/acsptsci.1c00080. eCollection 2021 Oct 8. ACS Pharmacol Transl Sci. 2021. PMID: 34651104 Free PMC article.
Heterologous immunity induced by 1^st generation COVID-19 vaccines and its role in developing a pan-coronavirus vaccine.
Patel RS, Agrawal B. Patel RS, et al. Front Immunol. 2022 Aug 15;13:952229. doi: 10.3389/fimmu.2022.952229. eCollection 2022. Front Immunol. 2022. PMID: 36045689 Free PMC article. Review.
Three doses of prototypic SARS-CoV-2 inactivated vaccine induce cross-protection against its variants of concern.
Xie T, Lu S, He Z, Liu H, Wang J, Tang C, Yang T, Yu W, Li H, Yang Y, Yang H, Yue L, Zhou Y, Yang F, Luo Z, Li Y, Xiang H, Zhao Y, Wang J, Wang H, Long R, Kuang D, Tan W, Peng X, Li Q, Xie Z. Xie T, et al. Signal Transduct Target Ther. 2022 Feb 25;7(1):61. doi: 10.1038/s41392-022-00920-4. Signal Transduct Target Ther. 2022. PMID: 35217639 Free PMC article.

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References

1. Polack FP, Thomas SJ, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. N Eng J Med. 2020;383:2603–2615. - PMC - PubMed
1. Baden LR, El Sahly HM, Essink B, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Eng J Med. 2020;384:403–416. - PMC - PubMed
1. Wibmer CK, Ayres F, Hermanus T, et al. SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. bioRxiv. 2021 doi: 10.1101/2021.01.18.427166. published online Jan 19. (preprint). - DOI - PubMed
1. Huang B, Dai L, Wang H, et al. Neutralization of SARS-CoV-2 VOC 501Y.V2 by human antisera elicited by both inactivated BBIBP-CorV and recombinant dimeric RBD ZF2001 vaccines. bioRxiv. 2021 doi: 10.1101/2021.02.01.429069. published online Feb 2. (preprint). - DOI
1. Wang Z, Schmidt F, Weisblum Y, et al. mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants. Nature. 2021 doi: 10.1038/s41586-021-03324-6. published online Feb 10. - DOI - PMC - PubMed

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[1] Polack FP, Thomas SJ, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. N Eng J Med. 2020;383:2603–2615. - PMC - PubMed

[2] Polack FP, Thomas SJ, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. N Eng J Med. 2020;383:2603–2615. - PMC - PubMed

[3] Baden LR, El Sahly HM, Essink B, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Eng J Med. 2020;384:403–416. - PMC - PubMed

[4] Baden LR, El Sahly HM, Essink B, et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Eng J Med. 2020;384:403–416. - PMC - PubMed

[5] Wibmer CK, Ayres F, Hermanus T, et al. SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. bioRxiv. 2021 doi: 10.1101/2021.01.18.427166. published online Jan 19. (preprint). - DOI - PubMed

[6] Wibmer CK, Ayres F, Hermanus T, et al. SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. bioRxiv. 2021 doi: 10.1101/2021.01.18.427166. published online Jan 19. (preprint). - DOI - PubMed

[7] Huang B, Dai L, Wang H, et al. Neutralization of SARS-CoV-2 VOC 501Y.V2 by human antisera elicited by both inactivated BBIBP-CorV and recombinant dimeric RBD ZF2001 vaccines. bioRxiv. 2021 doi: 10.1101/2021.02.01.429069. published online Feb 2. (preprint). - DOI

[8] Huang B, Dai L, Wang H, et al. Neutralization of SARS-CoV-2 VOC 501Y.V2 by human antisera elicited by both inactivated BBIBP-CorV and recombinant dimeric RBD ZF2001 vaccines. bioRxiv. 2021 doi: 10.1101/2021.02.01.429069. published online Feb 2. (preprint). - DOI

[9] Wang Z, Schmidt F, Weisblum Y, et al. mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants. Nature. 2021 doi: 10.1038/s41586-021-03324-6. published online Feb 10. - DOI - PMC - PubMed

[10] Wang Z, Schmidt F, Weisblum Y, et al. mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants. Nature. 2021 doi: 10.1038/s41586-021-03324-6. published online Feb 10. - DOI - PMC - PubMed

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Vaccines and SARS-CoV-2 variants: the urgent need for a correlate of protection

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Vaccines and SARS-CoV-2 variants: the urgent need for a correlate of protection

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