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. 2021;52(2):173-176.
doi: 10.1159/000514455. Epub 2021 Mar 25.

Sex Differences of Kidney Stone Urine Risk Factors after Roux-en-Y Gastric Bypass

Megan Prochaska  1 , John Asplin  2 , Arlene Chapman  1 , Elaine Worcester  1
Affiliations

Sex Differences of Kidney Stone Urine Risk Factors after Roux-en-Y Gastric Bypass

Megan Prochaska et al. Am J Nephrol. 2021.

Abstract

Introduction: Roux-en-Y gastric bypass (RYGB) is a bariatric surgical procedure that is associated with higher risk of kidney stones after surgery. We examined urine composition in 18 men and women before and after RYGB to examine differences in kidney stone risk.

Methods: Three 24-h urine collections were performed before and 1 year after RYGB. We analyzed mean urinary values for pre- and post-RYGB collections and compared men and women.

Results: Seven men and eleven women completed pre- and post-RYGB urine collections. Pre-RYGB, men had higher calcium oxalate supersaturation (CaOx SS) (7.0 vs. 5.0, p = 0.04) compared with women. Post-RYGB, women had higher urine CaOx SS (13.1 vs. 4.6, p = 0.002), calcium phosphate supersaturation (1.04 vs. 0.59, p = 0.05), and lower urine volumes (1.7 vs. 2.7L, p < 0.001) compared with men.

Discussion/conclusion: There are important differences in urine composition by sex that may contribute to higher kidney stone risk in women after RYGB compared with men.

Keywords: Calcium oxalate; Nephrolithiasis.

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Conflict of interest statement

Conflict of interest: No known conflicts of interest to disclose.

Comment in

  • Urolithiasis/Endourology.
    Assimos DG. Assimos DG. J Urol. 2021 Aug;206(2):470-472. doi: 10.1097/JU.0000000000001861. Epub 2021 May 11. J Urol. 2021. PMID: 33971728 No abstract available.

References

    1. Adams TD et al. Weight and Metabolic Outcomes 12 Years after Gastric Bypass. N. Engl. J. Med 377, 1143–1155 (2017). - PMC - PubMed
    1. Aminian A. et al. Association of Metabolic Surgery With Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes and Obesity. JAMA (2019) doi: 10.1001/jama.2019.14231. - DOI - PMC - PubMed
    1. Lieske JC et al. Kidney stones are common after bariatric surgery. Kidney Int. 87, 839–845 (2015). - PMC - PubMed
    1. Prochaska M, Taylor E, Ferraro PM & Curhan G. Relative Supersaturation of 24-Hour Urine and Likelihood of Kidney Stones. J. Urol 199, 1262–1266 (2018). - PMC - PubMed
    1. Asplin JR & Coe FL Hyperoxaluria in Kidney Stone Formers Treated With Modern Bariatric Surgery. J. Urol 177, 565–569 (2007). - PubMed

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