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Review
. 2021;12(1):335-337.
doi: 10.1016/j.jcmgh.2021.03.006. Epub 2021 Mar 23.

Thiopurine Use During Pregnancy Has Deleterious Effects on Offspring in Nudt15R138C Knock-In Mice

T Imai  1 , M Kawahara  2 , G Tatsumi  1 , N Yamashita  1 , A Nishishita-Asai  1 , O Inatomi  1 , A Masamune  3 , Y Kakuta  3 , A Andoh  1
Affiliations
Review

Thiopurine Use During Pregnancy Has Deleterious Effects on Offspring in Nudt15R138C Knock-In Mice

T Imai et al. Cell Mol Gastroenterol Hepatol. 2021.
No abstract available

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Figures

Figure 1
Figure 1
Thiopurine use during pregnancy induces harmful effects on offspring. The frequency of Nudt15 genotype in neonatal mice generated by Nudt15+/R138C female mice (A) or Nudt15+/+ female mice (B) that were mated with Nudt15+/R138C male mice and treated with the indicated MP dose during pregnancy. Dimethyl sulfoxide was administered instead of MP as a control. The numbers of analyzed neonatal mice and parental mice are presented for each MP dose. DMSO, dimethyl sulfoxide.
Figure 2
Figure 2
Thiopurine induces hematopoietic toxicity in fetal mice. Representative appearance (A) and the crown-rump length (B) of Nudt15+/+, Nudt15+/R138C, or Nudt15R138C/R138C fetal mice on embryonic day 14.5 generated by Nudt15+/R138C female mice that were mated with Nudt15+/R138C male mice and treated with 0.2 mg/kg MP during pregnancy. Scale bars indicate 5 mm. The numbers of parental male and female mice are 14, and 15, respectively. (C) The absolute number of HSCs in Nudt15+/+, Nudt15+/R138C, or Nudt15R138C/R138C fetal liver on embryonic day 14.5 is plotted. The means and standard deviations are indicated by horizontal bars and vertical bars, respectively. Significant P values with analysis of variance followed by Tukey test are described. DMSO, dimethyl sulfoxide.
See this image and copyright information in PMC

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