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Comment
. 2021 Jul;42(7):E37-E38.
doi: 10.3174/ajnr.A7092. Epub 2021 Mar 25.

Virtual Biopsy: A Reality Thanks to Advances in Radiology

M F V V Aragao  1   2 , A D P Oliveira  3 , A R M C Lima  4 , M C Leal  1   5 , M M Valenca  1
Affiliations
Comment

Virtual Biopsy: A Reality Thanks to Advances in Radiology

M F V V Aragao et al. AJNR Am J Neuroradiol. 2021 Jul.
No abstract available

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Figures

FIGURE.
FIGURE.
Brain MR imaging of a woman in her 40’s with confirmed COVID-19 shows injury of the olfactory bulbs, within 7 days of onset of the disease. A real-time polymerase chain reaction of a nasopharyngeal swab detected Severe Acute Respiratory Syndrome coronavirus 2, which was negative on her CSF. The MR imaging shows that the olfactory bulbs are oval images with signal intensity similar to that of gray matter on precontrast T1WI (A, arrows), being hypointense. On postcontrast T1WI (B, arrows), the olfactory bulbs show abnormal enhancement and become hyperintense, suggesting injury with breakdown of the brain-blood barrier. Two months later, the follow-up MR imaging shows that the contrast enhancement of the olfactory bulbs has completely disappeared and they have a normal appearance, being hypointense and similar to the gray matter on coronal postcontrast T1WI (C, arrows).
See this image and copyright information in PMC

Comment on

  • Microvascular Injury in the Brains of Patients with Covid-19.
    Lee MH, Perl DP, Nair G, Li W, Maric D, Murray H, Dodd SJ, Koretsky AP, Watts JA, Cheung V, Masliah E, Horkayne-Szakaly I, Jones R, Stram MN, Moncur J, Hefti M, Folkerth RD, Nath A. Lee MH, et al. N Engl J Med. 2021 Feb 4;384(5):481-483. doi: 10.1056/NEJMc2033369. Epub 2020 Dec 30. N Engl J Med. 2021. PMID: 33378608 Free PMC article. No abstract available.

References

    1. Aragao MFVVLeal MC, Cartaxo FO, et al. . Anosmia in COVID-19 associated with injury to the olfactory bulbs evident on MRI. AJNR Am J Neuroradiol 2020;41:1703–06 10.3174/ajnr.A6675 - DOI - PMC - PubMed
    1. Mamourian A. Seeing what we expect to see in COVID-19. AJNR Am J Neuroradiol 2021;42:E1 10.3174/ajnr.A6912 - DOI - PMC - PubMed
    1. Aragao MFVV, Leal MC, Fonseca TM, et al. . Reply. AJNR Am J Neuroradiol 2021;42:E2–E3 10.3174/ajnr.A6943 - DOI - PMC - PubMed
    1. Lee MH, Perl DP, Nair G, et al. . Microvascular injury in the brains of patients with Covid-19. N Engl J Med 2021;384:481–83 10.1056/NEJMc2033369 - DOI - PMC - PubMed

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