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Case Reports
. 2021 Mar 25;14(3):e237070.
doi: 10.1136/bcr-2020-237070.

Demyelinating polyneuropathy associated with chronic inactive hepatitis B infection

Mohamed A Babatin  1 , Awatef AlJohani  2
Affiliations
Case Reports

Demyelinating polyneuropathy associated with chronic inactive hepatitis B infection

Mohamed A Babatin et al. BMJ Case Rep. .

Abstract

This is a case report of a 42-year-old female patient with chronic inactive hepatitis B virus (HBV) infection who presented with relapsing chronic inflammatory demyelinating polyneuropathy (CIDP). Her initial attack was of acute onset (ie, acute CIDP) resembling Guillain-Barré syndrome that responded well to intravenous immunoglobulin (IVIG) therapy. The second episode was chronic and refractory to IVIG. She was managed with plasma exchange, long-term corticosteroids, immunosuppressants and HBV antiviral therapy. She showed both clinical and electromyographic improvement, with no recurrence after 2 years of follow-up.

Keywords: hepatitis B; neurological injury.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Motor curve showing prolonged onset of distal latency of the left medial nerve compared with the right and significant reduction in the amplitude compound motor action potential. APB, abductor pollicis brevis.
See this image and copyright information in PMC

References

    1. Sanai FM, Alghamdi H, Alswat KA, et al. . Greater prevalence of comorbidities with increasing age: cross-sectional analysis of chronic hepatitis B patients in Saudi Arabia. Saudi J Gastroenterol 2019;25:194–200. 10.4103/sjg.SJG_447_18 - DOI - PMC - PubMed
    1. Cacoub P, Saadoun D, Bourlière M, et al. . Hepatitis B virus genotypes and extrahepatic manifestations. J Hepatol 2005;43:764–70. 10.1016/j.jhep.2005.05.029 - DOI - PubMed
    1. Aljumah AA, Babatin M, Hashim A, et al. . Hepatitis B care pathway in Saudi Arabia: current situation, gaps and actions. Saudi J Gastroenterol 2019;25:73–80. 10.4103/sjg.SJG_421_18 - DOI - PMC - PubMed
    1. Tsukada N, Koh CS, Inoue A, et al. . Demyelinating neuropathy associated with hepatitis B virus infection. detection of immune complexes composed of hepatitis B virus surface antigen. J Neurol Sci 1987;77:203–16. 10.1016/0022-510x(87)90123-7 - DOI - PubMed
    1. Mason A, Wick M, White H, et al. . Hepatitis B virus replication in diverse cell types during chronic hepatitis B virus infection. Hepatology 1993;18:781–9 https://pubmed.ncbi.nlm.nih.gov/8406351/10.1002/hep.1840180406 - DOI - PubMed

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