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. 2020 Sep;8(3):75-86.
doi: 10.1007/s40139-020-00209-7. Epub 2020 Jul 28.

Impact of Alcohol on Bone Health, Homeostasis and Fracture repair

Jonathan M Eby  1   2 , Farah Sharieh  1   2 , John J Callaci  1   2
Affiliations

Impact of Alcohol on Bone Health, Homeostasis and Fracture repair

Jonathan M Eby et al. Curr Pathobiol Rep. 2020 Sep.

Abstract

Purpose of review: Alcohol use continues to rise globally. We review the current literature on the effect of alcohol on bone health, homeostasis and fracture repair to highlight what has been learned in people and animal models of alcohol consumption.

Recent findings: Recently, forkhead box O (FoxO) has been found to be upregulated and activated in mesenchymal stem cells (MSC) exposed to alcohol. FoxO has also been found to modulate Wnt/β-catenin signaling, which is necessary for MSC differentiation. Recent evidence suggests alcohol activates FoxO signaling, which may be dysregulating Wnt/β-catenin signaling in MSCs cultured in alcohol.

Summary: This review highlights the negative health effects learned from people and chronic and episodic binge alcohol consumption animal models. Studies using chronic alcohol exposure or alcohol exposure then bone fracture repair model have explored several different cellular and molecular signaling pathways important for bone homeostasis and fracture repair, and offer potential for future experiments to explore additional signaling pathways that may be dysregulated by alcohol exposure.

Keywords: FoxO; Wnt/β-catenin signaling; alcohol; fracture; mesenchymal stem cells; oxidative stress.

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Conflict of interest statement

Conflict of Interest: Jonathan M. Eby, Farah Sharieh, and John J. Callaci declare that they have no conflict of interest.

Figures

Figure 1:
Figure 1:
Hypothesized effect of alcohol inhibition in mesenchymal stem cells at the fracture site.m
See this image and copyright information in PMC

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