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. 2020 Dec;19(4):402-411.
doi: 10.1007/s11901-020-00543-9. Epub 2020 Sep 9.

Exercise as Medicine: The Impact of Exercise Training on Nonalcoholic Fatty Liver Disease

Audrey Thorp  1 , Jonathan G Stine  2   3   4   5
Affiliations

Exercise as Medicine: The Impact of Exercise Training on Nonalcoholic Fatty Liver Disease

Audrey Thorp et al. Curr Hepatol Rep. 2020 Dec.

Abstract

Purpose of review: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of global liver disease. Because current pharmacologic treatments are ineffective, lifestyle change centered on exercise remains the most effective NAFLD treatment. The aim of this systematic review is to summarize and evaluate the current evidence supporting the use of exercise training as a medical treatment for adult patients with NAFLD.

Recent findings: At least 150 minutes each week of moderate intensity exercise of any type can improve NAFLD, both with and without modest weight loss. Exercise training reduces hepatic steatosis and liver inflammation, favorably changes body composition, improves vascular endothelial function, increases cardiorespiratory fitness and can lead to histologic response. To date, exercise-based NAFLD trials are limited by small sample size and significant heterogeneity.

Summary: While several key questions remain unanswered, exercise training will always be an important part of the medical management of patients with NAFLD.

Keywords: cardiovascular disease; fatty liver; lifestyle modification; nonalcoholic steatohepatitis; physical activity.

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Figures

Figure 1.
Figure 1.
Benefits of exercise training in patients with NAFLD
See this image and copyright information in PMC

References

    1. Younossi ZM, et al., Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology, 2016. 64(1): p. 73–84. - PubMed
    1. Sanyal AJ, et al., Endpoints and clinical trial design for nonalcoholic steatohepatitis. Hepatology, 2011. 54(1): p. 344–53. - PMC - PubMed
    1. Ludwig J, et al., Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc, 1980. 55(7): p. 434–8. - PubMed
    1. Lam B, Kurzke K, and Younossi Z, The Clinical and Economic Burden of Nonalcoholic Steatohepatitis. Current Hepatology Reports, 2018. 17(4): p. 345–349.
    1. *Croci I, et al., Non-alcoholic fatty liver disease: Prevalence and all-cause mortality according to sedentary behaviour and cardiorespiratory fitness. The HUNT Study. Prog Cardiovasc Dis, 2019. 62(2): p. 127–134. - PubMed

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