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. 2021 Feb 17;8(3):002309.
doi: 10.12890/2021_002309. eCollection 2021.

Chronic Copper Sulfate Poisoning

Affiliations

Chronic Copper Sulfate Poisoning

Ana Paula Perestrelo et al. Eur J Case Rep Intern Med. .

Abstract

Copper, as a salt, is toxic and has the potential to harm multiple organs. Copper intoxication causes intravascular haemolysis followed by liver and kidney failure that can be fatal. We present a case of chronic copper sulfate poisoning in a 66-year-old man with dysphagia to solids and liquids, anaemia, acute kidney injury, liver cytolysis and hypocalcaemia. The patient improved with supportive care, but chronic kidney disease was established. Anamnesis was crucial for the diagnosis, given the non-specific signs and symptoms. The history of chronic exposure to pest treatment with a blue dust cloud made us suspect copper sulfate poisoning.

Learning points: Copper sulfate poisoning is a relatively uncommon illness nowadays but can still be seen in clinical practice and should be kept in mind.It has non-specific signs and symptoms such as dysgeusia, abdominal pain, vomiting, muscle cramps or spasms, diarrhoea, ink-like urine, jaundice, anaemia and seizures.The diagnosis is based on clinical presentation and laboratory examinations upon a history of exposure to copper sulfate-containing products.

Keywords: Copper sulfate poisoning; kidney injury.

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Conflict of interest statement

Conflicts of Interests: The Authors declare that there are no competing interests.

References

    1. Arena M, Auteri D, Barmaz S, Bellisai G, Brancato A, Brocca D, et al. Peer review of the pesticide risk assessment of the active substance copper compounds copper(I), copper(II) variants namely copper hydroxide, copper oxychloride, tribasic copper sulfate, copper(I) oxide, Bordeaux mixture. EFSA J. 2018;16(1):e05152. - PMC - PubMed
    1. Gunay N, Yildirim C, Karcioglu O, Gunay NE, Yilmaz M, Usalan C, et al. A series of patients in the emergency department diagnosed with copper poisoning: recognition equals treatment. Tohoku J Exp Med. 2006;209(3):243–248. - PubMed
    1. Gamakaranage CS, Rodrigo C, Weerasinghe S, Gnanathasan A, Puvanaraj V, Fernando H. Complications and management of acute copper sulphate poisoning; a case discussion. J Occup Med Toxicol. 2011;6(1):34. - PMC - PubMed
    1. Yang CC, Wu ML, Deng JF. Prolonged hemolysis and methemoglobinemia following organic copper fungicide ingestion. Vet Hum Toxicol. 2004;46(6):321–323. - PubMed
    1. Faure A, Mathon L, Poupelin JC, Allaouchiche B, Chassard D. Acute cupric sulfate intoxication: pathophysiology and therapy about a case report. Ann Fr Anesth Reanim. 2003;22(6):557–559. - PubMed

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