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Review
. 2021 Mar 8;5(1):e001011.
doi: 10.1136/bmjpo-2020-001011. eCollection 2021.

Early recognition of PIMS-TS: a single centre retrospective review

Roshni Mistry  1 , Nicola Scanlon  2 , James Hibberd  3   4 , Fionnghuala Fuller  2
Affiliations
Review

Early recognition of PIMS-TS: a single centre retrospective review

Roshni Mistry et al. BMJ Paediatr Open. .

Abstract

Introduction: Research into paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) has focused on tertiary level management. This review reports on symptoms and investigations at presentation.

Methods: Single centre retrospective case note analysis of patients fulfilling PIMS-TS diagnostic criteria from March to May 2020 in a London district level university hospital.

Results: Six patients presented in the week prior to their final diagnosis with fever and non-specific symptoms. Raised C-reactive protein (CRP), lymphopenia and hyponatraemia were noted. Kawasaki-like symptoms were under-represented in all patients.

Interpretation: The results suggest that a proportion of children with early PIMS-TS present with a non-specific febrile illness and abnormal blood results. Further research is needed to determine the most appropriate identification and follow-up of these children.

Keywords: COVID-19; virology.

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Conflict of interest statement

Competing interests: None declared.

References

    1. Public Health England . Disparities in the risk and outcomes of COVID-19 – August 2020. Phe: London, 2020. Available: https://assets.publishing.service.gov.uk/government/uploads/system/uploa...
    1. Royal College of Paediatrics and Child Health . Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 (PIMS) - guidance for clinicians – 01 May 2020. RCPCH: London, 2020. Available: https://www.rcpch.ac.uk/resources/guidance-paediatric-multisystem-inflam...
    1. Ahmed M, Advani S, Moreira A. Multisystem inflammatory syndrome in children: a systematic review. The Lancet 2020;26. - PMC - PubMed
    1. Verdoni L, Mazza A, Gervasoni A, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. The Lancet 2020;395:1771–8. 10.1016/S0140-6736(20)31103-X - DOI - PMC - PubMed
    1. Davies P, Evans C, Kanthimathinathan HK. Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study. The Lancet 2020;4:699–677. - PMC - PubMed

Supplementary concepts