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. 2021 Oct;76(10):2998-3016.
doi: 10.1111/all.14828. Epub 2021 Apr 25.

Markers for the involvement of endothelial cells and the coagulation system in chronic urticaria: A systematic review

Yora Mostmans  1   2 , Katleen De Smedt  3 , Bertrand Richert  2 , Daniel Elieh Ali Komi  4 , Marcus Maurer  5 , Olivier Michel  1
Affiliations

Markers for the involvement of endothelial cells and the coagulation system in chronic urticaria: A systematic review

Yora Mostmans et al. Allergy. 2021 Oct.

Abstract

Chronic urticaria (CU) is a chronic inflammatory mast cell-driven disorder. Endothelial cells (ECs) contribute importantly to key features of CU. Several markers of EC (dys)function in CU have been reported, but have not yet been systematically reviewed. In this study, we systematically reviewed and categorized all published markers of EC functions in CU through a comprehensive search in Pubmed, The Cochrane Library, Web of Science, and SCOPUS using the following Mesh terms: CU AND pathogenesis AND (vasculopathy OR microangiopathy OR ECs OR marker). In total, 79 articles were selected and the identified biomarkers were categorized according to EC (dys)function in CU. The most frequent and consistently reported upregulated biomarkers in CU skin were adhesion molecules, TF, and P-selectin. The most frequently reported upregulated and reliable biomarkers in sera of CU patients were F1+2 for coagulation cascade involvement, D-dimers for fibrinolysis, and MMP-9 for vascular permeability. Emerging biomarkers described in the selected articles were endostatin, heat shock proteins, cleaved high molecular weight kininogen, and adipokines. This systematic review contributes to the pool of growing evidence for vascular involvement in CU where EC dysfunction is present in different aspects of cell survival, maintenance of vascular structure, and coagulation/fibrinolysis balance.

Keywords: biomarker; chronic urticaria; coagulation and fibrinolysis; endothelial cell; vascular involvement.

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References

REFERENCES

    1. Church MK, Kolkhir P, Metz M, Maurer M. The role and relevance of mast cells in urticaria. Immunol Rev. 2018;282(1):232-247.
    1. Maurer M, Eyerich K, Eyerich S, et al. Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020. Int Arch Allergy Immunol. 2020;181(5):321-333.
    1. Burger D, Touyz RM. Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells. J Am Soc Hypertens. 2012;6(2):85-99.
    1. Haas N, Motel K, Czarnetzki BM. Comparative immunoreactivity of the eosinophil constituents MBP and ECP in different types of urticaria. Arch Dermatol Res. 1995;287(2):180-185.
    1. Hermes B, Prochazka AK, Haas N, Jurgovsky K, Sticherling M, Henz BM. Upregulation of TNF-alpha and IL-3 expression in lesional and uninvolved skin in different types of urticaria. J Allergy Clin Immunol. 1999;103(2 Pt 1):307-314.

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