Emerging antifungal treatment failure of dermatophytosis in Europe: take care or it may become endemic

D M L Saunte^{1

2

3}, M Pereiro-Ferreirós^{1

4}, C Rodríguez-Cerdeira^{1

5}, A Y Sergeev^{1

6}, M Arabatzis^{1

7}, A Prohić^{1

8}, B M Piraccini^{1

9}, P Lecerf^{1

10}, P Nenoff^{1

11}, L P Kotrekhova¹², P P Bosshard¹³, V Padovese¹⁴, J C Szepietowski^{1

15}, B Sigurgeirsson^{1

16}, R J Nowicki^{1

17}, P Schmid-Grendelmeier^{1

18}, R J Hay^{1

19}

Affiliations

¹ European Academy of Dermatology and Venereology TASK force on Mycology.
² Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
³ Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
⁴ Dermatología, Faculty of Medicine, University of Santiago de Compostela, A Coruña, Spain.
⁵ Department of Dermatology, Meixoeiro Hospital and University of Vigo, Vigo, Spain.
⁶ Department of Clinical Immunology, Sechenov University, Moscow, Russia.
⁷ Department of Dermatology, Medical School, Aristotle University, Thessaloniki, Greece.
⁸ Department of Dermatovenereology, University Sarajevo School of Science and Technology, Sarajevo Medical School, Sarajevo, Bosnia and Herzegovina.
⁹ Dermatology -IRCCS Policlinico di Sant'Orsola Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Bologna, Italy.
¹⁰ Department of Dermatology, University Hospital Brugmann & Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium.
¹¹ Laboratory for Medical Microbiology, Mölbis, Germany.
¹² Department of Dermatovenereology, North Western State Medical University, Saint Petersburg, Russia.
¹³ Department of Dermatology, University Hospital Zurich and Medical Faculty, University of Zurich, Zurich, Switzerland.
¹⁴ Department of Dermatology and Venereology, Genitourinary Clinic, Mater Dei Hospital, Msida, Malta.
¹⁵ Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
¹⁶ Department of Dermatology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
¹⁷ Department of Dermatology, Venereology & Allergology, Medical University of Gdansk, Gdansk, Poland.
¹⁸ Allergy Unit, Department of Dermatology, University Hospital Zurich and Medical Faculty, University of Zurich, Zurich, Switzerland.
¹⁹ St John's Institute of Dermatology, Kings College London, London, UK.

PMID: 33768571
DOI: 10.1111/jdv.17241

Emerging antifungal treatment failure of dermatophytosis in Europe: take care or it may become endemic

D M L Saunte et al. J Eur Acad Dermatol Venereol. 2021 Jul.

. 2021 Jul;35(7):1582-1586.

doi: 10.1111/jdv.17241. Epub 2021 Apr 22.

Authors

Affiliations

¹ European Academy of Dermatology and Venereology TASK force on Mycology.
² Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
³ Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
⁴ Dermatología, Faculty of Medicine, University of Santiago de Compostela, A Coruña, Spain.
⁵ Department of Dermatology, Meixoeiro Hospital and University of Vigo, Vigo, Spain.
⁶ Department of Clinical Immunology, Sechenov University, Moscow, Russia.
⁷ Department of Dermatology, Medical School, Aristotle University, Thessaloniki, Greece.
⁸ Department of Dermatovenereology, University Sarajevo School of Science and Technology, Sarajevo Medical School, Sarajevo, Bosnia and Herzegovina.
⁹ Dermatology -IRCCS Policlinico di Sant'Orsola Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Bologna, Italy.
¹⁰ Department of Dermatology, University Hospital Brugmann & Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium.
¹¹ Laboratory for Medical Microbiology, Mölbis, Germany.
¹² Department of Dermatovenereology, North Western State Medical University, Saint Petersburg, Russia.
¹³ Department of Dermatology, University Hospital Zurich and Medical Faculty, University of Zurich, Zurich, Switzerland.
¹⁴ Department of Dermatology and Venereology, Genitourinary Clinic, Mater Dei Hospital, Msida, Malta.
¹⁵ Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
¹⁶ Department of Dermatology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
¹⁷ Department of Dermatology, Venereology & Allergology, Medical University of Gdansk, Gdansk, Poland.
¹⁸ Allergy Unit, Department of Dermatology, University Hospital Zurich and Medical Faculty, University of Zurich, Zurich, Switzerland.
¹⁹ St John's Institute of Dermatology, Kings College London, London, UK.

PMID: 33768571
DOI: 10.1111/jdv.17241

Abstract

Background: Dermatophytosis is a world-wide distributed common infection. Antifungal drug resistance in dermatophytosis used to be rare, but unfortunately the current Indian epidemic of atypical widespread recalcitrant and terbinafine-resistant dermatophytosis is spreading and has sporadically been reported in Europe.

Objectives: To explore the occurrence of clinical and mycological proven antifungal drug resistance in dermatophytes in Europe.

Methods: A standardized questionnaire was distributed through the EADV Task Force of Mycology network to dermatologists in Europe.

Results: Representatives from 20 countries completed the questionnaires of which 17 (85 %) had observed clinical and/or mycological confirmed antifungal resistance, two countries published cases of antifungal resistance and one country had no known cases.

Conclusions: This pilot study confirms that both clinical and mycological antifungal resistance exist in Europe.

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References

1. Verma S, Vasani R, Reszke R, Matusiak SJC. Prevalence and clinical characteristics of itch in epidemic-like scenario of dermatophytoses in India: a cross-sectional study. J Eur Acad Dermatology Venereol 2020; 34: 180-183.
1. Chen X, Jiang X, Yang M et al. Systemic antifungal therapy for tinea capitis in children. Cochrane Database Syst Rev 2016:CD004685.
1. Ebert A, Monod M, Salamin K et al. Alarming India-wide phenomenon of antifungal resistance in dermatophytes: A multicentre study. Mycoses 2020; 63: 717-728.
1. Singh A, Masih A, Khurana A et al. High terbinafine resistance in Trichophyton interdigitale isolates in Delhi, India harbouring mutations in the Squalene epoxidase (SQLE) gene. Mycoses 2018; 61: 477-484.
1. Rudramurthy SM, Shankarnarayan SA, Dogra S et al. Mutation in the squalene epoxidase gene of trichophyton interdigitale and trichophyton rubrum associated with allylamine resistance. Antimicrob Agents Chemother 2018; 62: e02522-e2617.

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Emerging antifungal treatment failure of dermatophytosis in Europe: take care or it may become endemic

Affiliations

Emerging antifungal treatment failure of dermatophytosis in Europe: take care or it may become endemic

Authors

Affiliations

Abstract

References

MeSH terms

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LinkOut - more resources

Full Text Sources

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Medical