Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Jan 13;9(3):1066-1071.
doi: 10.1002/ccr3.3593. eCollection 2021 Mar.

Diagnosis of maternal Hodgkin lymphoma following abnormal findings at noninvasive prenatal screening test (NIPT): Report of two cases

Alessia Castellino  1 , Simona Elba  1 , Roberto Sorasio  1 , Claudia Castellino  1 , Margherita Bonferroni  1 , Mariella Grasso  1 , Enrico Grosso  2 , Rosalba Giacchello  3 , Anna Franca Signorile  1 , Ivana Celeghini  1 , Daniele Mattei  1 , Nicola Mordini  1 , Myriam Foglietta  1 , Bianca Masturzo  2 , Roberto Priotto  1 , Andrea Zonta  2 , Davide Rapezzi  1 , Massimo Massaia  1
Affiliations
Case Reports

Diagnosis of maternal Hodgkin lymphoma following abnormal findings at noninvasive prenatal screening test (NIPT): Report of two cases

Alessia Castellino et al. Clin Case Rep. .

Abstract

Abnormal NIPT results, contrasting with normal fetus development, could disclose maternal malignancy, and this possibility should always be explained during pretest counseling. In this case, a complete diagnostic assessment is recommended and should be managed by a multidisciplinary team to define the best timing for diagnostic procedures, delivery, and treatment.

Keywords: hematology.

PubMed Disclaimer

Conflict of interest statement

Castellino, Elba, Sorasio, Castellino, Bonferroni, Grasso, Grosso, Giacchello, A. F. Signorile, Celeghini, Mattei, Mordini, Foglietta, Masturzo, Priotto, Zonta, Rapezzi, Massaia: nothing to disclose.

Figures

FIGURE 1
FIGURE 1
Case 1. RJ. A‐T2: MRI results at diagnosis, showing mediastinal mass (T2 sequences). A‐Dw: MRI results at diagnosis, showing mediastinal mass (Dw sequences). B‐T2: MRI at the end of treatment, showing complete regression of mediastinal mass (T2 sequences). B‐Dw: MRI at the end of treatment, showing regression of diffusion signal (Dw sequences). B‐PET: CT‐PET scan at the end of treatment, showing complete remission, Deauville score 3
FIGURE 2
FIGURE 2
Case 2. FV. A‐T2: MRI results at diagnosis, showing mediastinal mass (T2 sequences). A‐Dw: MRI results at diagnosis, showing mediastinal mass (Dw sequences). B‐T2: MRI at the end of treatment, showing complete regression of mediastinal mass (T2 sequences). B‐Dw: MRI at the end of treatment, showing regression of diffusion signal (Dw sequences). B‐PET: CT‐PET scan at the end of treatment, showing complete remission, Deauville score 3
See this image and copyright information in PMC

References

    1. Benn P, Plon SE, Bianchi DW. Current controversies in prenatal diagnosis 2: NIPT results suggesting maternal cancer should always be disclosed. Prenat Diagn. 2018;39(5):339‐343. - PMC - PubMed
    1. Chiu RW, Chan KC, Gao Y, et al. Non invasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. Proc Natl Acad Sci USA. 2008;105(51):20458‐20463. - PMC - PubMed
    1. Hartwig TS, Ambye L, Sørensen S, et al. Discordant non‐invasive prenatal testing (NIPT) ‐ a systematic review. Prenat Diagn. 2017;37(6):527‐539. - PubMed
    1. Pavlidis NA. Coesistence of pregnancies and malignancies. Oncologist. 2002;7(4):279‐287.Review. Erratum. In: Oncologist 2002;7(6):585. - PubMed
    1. Amant F, Verheevke M, Wlodarska I, et al. Presymptomatic identification of cancers in pregnant women during non invasive prenatal testing. JAMA Oncol. 2015;1:814‐819. - PubMed

Publication types