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Case Reports
. 2021 Jan 26;9(3):1387-1392.
doi: 10.1002/ccr3.3780. eCollection 2021 Mar.

Hemosiderotic dermatofibroma mimicking melanoma: A case report and review of the literature

Changzhao Li  1 , Hunter Allen  2 , Margarita Loxas  2 , Poonam Sharma  1
Affiliations
Case Reports

Hemosiderotic dermatofibroma mimicking melanoma: A case report and review of the literature

Changzhao Li et al. Clin Case Rep. .

Abstract

Hemosiderotic dermatofibroma (HDF) often mimics melanoma clinically. A definite diagnosis relies on histopathological evaluation and immunohistochemistry. As it can progress to aneurysmal dermatofibroma (ADF), complete excision is recommended.

Keywords: aneurysmal dermatofibroma; hemosiderotic dermatofibroma; melanoma; skin.

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Conflict of interest statement

The authors declare no conflict of interests.

Figures

FIGURE 1
FIGURE 1
Picture showing a black skin lesion with an ill‐defined boarder on the left thigh
FIGURE 2
FIGURE 2
Representative picture shows A, fibrohistiocytic proliferation in the dermis with Grenz zone, acanthosis, and focal epidermal basal layer hyperpigmentation, original magnification 40×; B, diffuse intracellular hemosiderin deposition in histiocytes, original magnification 400×; C, Prussian blue stain, original magnification 400X; (D) peripheral collagen entrapment by fibrohistiocytes, original magnification 400×; E, extravasation of RBCs into the interstitial spaces, engulfment of RBCs by macrophages, and production of intracellular hemosiderin; and F, area with abundant foamy histiocytes and lipoblasts, original magnification, 400×
FIGURE 3
FIGURE 3
Pictures showing immunohistochemistry staining of (A) CD10; (B) FXIIIa; (C) CD68; (D) HMB‐45; and (E) SOX‐10
See this image and copyright information in PMC

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