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Review
. 2021 Aug 3;17(8):2626-2629.
doi: 10.1080/21645515.2021.1885282. Epub 2021 Mar 26.

Pembrolizumab for choroidal metastases from non-small cell lung cancer: a case report and literature review

Xinsheng Li  1 , Ya Liang  1 , Jingfan Wang  1 , Zizhong Hu  1 , Zhi-Lan Yuan  1 , Ping Xie  1
Affiliations
Review

Pembrolizumab for choroidal metastases from non-small cell lung cancer: a case report and literature review

Xinsheng Li et al. Hum Vaccin Immunother. .

Abstract

We described a 65-year-old male with choroidal metastases (CM) from non-small cell lung cancer (NSCLC). Pembrolizumab (Keytruda) combined with pemetrexed and capecitabine achieved excellent outcomes. After two cycles of pembrolizumab and chemotherapy, blurred vision and left eye pain were significantly relieved. Imaging and ophthalmologic examinations demonstrated complete resolution of the CM, as well as reduction of pulmonary shadow. CM from NSCLC shows complete and durable response to pembrolizumab and chemotherapy. We suggesting that immunotherapy combined with chemotherapy is a promising treatment for CM from NSCLC.

Keywords: Immunotherapy; choroidal metastases; non-small cell lung cancer; pembrolizumab.

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Figures

Figure 1.
Figure 1.
Ocular and medical imaging examination of pre-immunotherapy. (a) Ocular ultrasonography. (b) The early stage of FFA. (c) The late stage of FFA. (d) ICGA of fundus. (e) Chest high-resolution CT. (f) MRI of brain
Figure 2.
Figure 2.
Ocular and medical imaging examination of post-immunotherapy. (a) Ocular ultrasonography. (b) The early stage of FFA. (c) The late stage of FFA. (d) Chest high-resolution CT
See this image and copyright information in PMC

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