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. 2021 Jun 1;78(6):682-683.
doi: 10.1001/jamapsychiatry.2021.0500.

How COVID-19 Affects the Brain

Maura Boldrini  1   2 , Peter D Canoll  3 , Robyn S Klein  4   5   6
Affiliations

How COVID-19 Affects the Brain

Maura Boldrini et al. JAMA Psychiatry. .
No abstract available

PubMed Disclaimer

Figures

Figure.
Figure.. Brain Vascular Injury, Neurotransmitter System Dysfunction, Thrombotic Events, Neuronal Damage, and Neuropsychiatric Symptoms
A, SARS-CoV-2 invades endothelial cells via transmembrane angiotensin-converting enzyme 2 (ACE2) receptor, enabled by transmembrane protease, serine 2 (TMPRSS2). B, Cytokine elevation and microglia activation result in increased kynurenine, quinolinic acid, and glutamate, and neurotransmitter depletion. C, Coagulation cascade and elevation of von Willebrand factor (vWF) lead to thrombotic events. D, Altered neurotransmission, excitotoxicity by increased glutamate, and hypoxic injury contribute to neuronal dysfunction and loss. E, Neuropsychiatric symptoms differ depending on the Brodmann area involved. IL indicates interleukin; NMDA, N-methyl-d-aspartate; TNF, tumor necrosis factor.
See this image and copyright information in PMC

References

    1. Woo MS, Malsy J, Pöttgen J, et al. Frequent neurocognitive deficits after recovery from mild COVID-19. Brain Commun. 2020;2(2):fcaa205. doi:10.1093/braincomms/fcaa205 - DOI - PMC - PubMed
    1. Meinhardt J, Radke J, Dittmayer C, et al. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nat Neurosci. 2021;24(2):168–175. - PubMed
    1. Roman M, Irwin MR. Novel neuroimmunologic therapeutics in depression. Brain Behav Immun. 2020;83:7–21. doi:10.1016/j.bbi.2019.09.016 - DOI - PMC - PubMed
    1. Daniels BP, Holman DW, Cruz-Orengo L, Jujjavarapu H, Durrant DM, Klein RS. Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals. mBio. 2014;5(5):e01476–e14. doi:10.1128/mBio.01476-14 - DOI - PMC - PubMed
    1. Al-Dalahmah O, Thakur KT, Nordvig AS, et al. Neuronophagia and microglial nodules in a SARS-CoV-2 patient with cerebellar hemorrhage. Acta Neuropathol Commun. 2020;8(1):147. doi:10.1186/s40478-020-01024-2 - DOI - PMC - PubMed

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